Phenotype Image Detail

Image

Caption

A: Cyanosis in the newborn Atf2^tm1Glm/Atf2^tm1Glm (-/-) pups. The newborn pups generated by mating between Atf2^tm1Glm/Atf2⁺ heterozygotes (+/-) are indicated. The color of the mutant is pale, indicating cyanosis. B: Presence of meconium in the mutant lung. The lung sections were prepared from the wild-type (+/+) and mutants and analyzed by microscopy. The mutant lung contains meconium. C: Absence of air in the mutant lung. The lungs were prepared from newborn pups and were then put into PBS solution. The lungs from the wild-type or heterozygote floated on PBS, whereas those from mutants sank to the bottom of the container containing PBS.

Copyright

This image is from Maekawa T, J Biol Chem 1999 Jun 18;274(25):17813-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:55657

Associated Alleles

Symbol	Name
Atf2^tm1Sis	activating transcription factor 2; targeted mutation 1, Shunsuke Ishii

Associated Genotypes

Allelic Composition	Genetic Background
Atf2^tm1Sis/Atf2^tm1Sis	either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)