Phenotype Image Detail

Image

Caption

Radiographs of the skeletal abnormalities in 7 month old Smad3^tm1Cxd/Smad3^tm1Cxd (-/-) mice. A and B: Whole-mount view of wild-type (+/+) and mutant skeletons. Mutant mice exhibited increased intensities in vertebral and knee joints (arrowheads). C-H: Enlarged views of knee (C and D), vertebral (E and F), and sternum joints (G and H). The increased density in mutant joints is caused by formation of extra bones (arrowheads). However, decreased bone densities were found in other areas of mutant bones compared with corresponding regions of wild-type mice.

Copyright

This image is from Yang X, J Cell Biol 2001 Apr 2;153(1):35-46, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:68792

Associated Alleles

Symbol	Name
Smad3^tm1Cxd	SMAD family member 3; targeted mutation 1, Chu-Xia Deng

Associated Genotypes

Allelic Composition	Genetic Background
Smad3^tm1Cxd/Smad3^tm1Cxd	involves: 129S6/SvEvTac