Phenotype Image Detail

Image

Caption

Deficiencies in mesoderm formation begin at gastrulation in Prkar1a^tm1Gsm/Prkar1a^tm1Gsm mice. A: Representative eosin-hematoxylin-stained 8-m section through a wild-type E6.5 late streak stage embryo. Note the thick and highly ordered columns of mesodermal cells that have exited the primitive streak and moved laterally and anteriorly. Inset, outline of the embryo showing the approximate location of the section. B: Representative eosin-hematoxylin-stained 8-m section through an Prkar1a^tm1Gsm/Prkar1a^tm1Gsm late streak stage embryo. Note the reduced number of mesodermal cells that have exited the streak and the highly disorganized manner in which the cells have exited the streak to move anteriorly. Inset, outline of the embryo showing the approximate location of the section. Scale bar: A and B, 50 um. The abbreviations used are as follows: ant, anterior; ect, ectoderm; end, endoderm; mes, mesoderm; pos, posterior; ps, primitive streak.

Copyright

This image is from Amieux PS, J Biol Chem 2002 Jul 26;277(30):27294-304 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78010

Associated Alleles

Symbol	Name
Prkar1a^tm1Gsm	protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight

Associated Genotypes

Allelic Composition	Genetic Background
Prkar1a^tm1Gsm/Prkar1a^tm1Gsm	involves: 129X1/SvJ * C57BL/6