Phenotype Image Detail

Image

Caption

Phenotype of wild-type and Eif2ak4^tm1Drc/Eif2ak4^tm1Drc mice fed a leucine-devoid diet for 6 days. Wild-type (GCN2^+/+ -LEU, left) and Eif2ak4^tm1Drc/Eif2ak4^tm1Drc (GCN2^-/-HH -LEU, right) mice. Mutant mice appeared scruffy and lethargic in appearance following the leucine-deficient diet.

Copyright

This image is from Anthony TG, J Biol Chem 2004 Aug 27;279(35):36553-61 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:92545

Associated Alleles

Symbol	Name
Eif2ak4^tm1Drc	eukaryotic translation initiation factor 2 alpha kinase 4; targeted mutation 1, Douglas R Cavener

Associated Genotypes

Allelic Composition	Genetic Background
Eif2ak4^tm1Drc/Eif2ak4^tm1Drc	involves: 129S6/SvEvTac * C57BL/6