Phenotype Image Detail

Image

Caption

A: Dorsal view of 10 day old wild-type and Krt6a/Krt6b^tm1Cou/Krt6a/Krt6b^tm1Cou mice. Note the size difference between the littermates. B: Wild-type tongue. The surface is smooth and uniform. C: Tongue from mutant mouse. White plaques cover the dorsal surface, extending from the posterior region (right) near the pharynx towards, but not reaching, the tip of the tongue (left). D: Paws from wild-type mice are similar to mutant mice. E: The paw of the mutant mouse appears smaller, probably due to poor nutrition and slow growth. Development of fur and nails do not appear altered in mutant mice.

Copyright

This image is from Wong P, J Cell Biol 2000 Aug 21;150(4):921-8, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:64033

Associated Alleles

Symbol	Name
Krt6a/Krt6b^tm1Cou	keratin 6A; targeted mutation 1, Pierre A Coulombe
Krt6a/Krt6b^tm1Cou	keratin 6B; targeted mutation 1, Pierre A Coulombe

Associated Genotypes

Allelic Composition	Genetic Background
Krt6a/Krt6b^tm1Cou/Krt6a/Krt6b^tm1Cou	involves: 129S2/SvPas * C57BL/6 * DBA/2
Krt6a/Krt6b^tm1Cou/Krt6a/Krt6b^tm1Cou	involves: 129S2/SvPas * C57BL/6 * DBA/2