Phenotype Image Detail

Image

Caption

Electron micrographs of the basal aspect of wild type and Slc4a2^tm1Ges/Slc4a2^tm1Ges parietal cells. A: Wild type parietal cell with normal canalicular (C) and basolateral membranes (arrows). B: Slc4a2^tm1Ges/Slc4a2^tm1Ges parietal cells exhibited altered basolateral membrane (arrows) morphology characterized by an increase in the number and extent of infolding into the cell cytoplasm. Also note mitochondria (M) with altered ring-shaped or "donut" morphology. Scale bar: 2um.

Copyright

This image is from Gawenis LR, J Biol Chem 2004 Jul 16;279(29):30531-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:91617

Associated Alleles

Symbol	Name
Slc4a2^tm1Ges	solute carrier family 4 (anion exchanger), member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc4a2^tm1Ges/Slc4a2^tm1Ges	involves: 129S6/SvEvTac * Black Swiss