Phenotype Image Detail

Image

Caption

Electron microscopic comparison of wild type and Slc4a2^tm1Ges/Slc4a2^tm1Ges parietal cells. A: Wild type parietal cell showing well developed secretory canaliculi. B: Slc4a2^tm1Ges/Slc4a2^tm1Ges parietal cell with the secretory microvilli confined to the apical surface of the cell. Note that membranes with secretory microvilli do not extend into the cytoplasm to form secretory canaliculi. C: Flattened mutant parietal cell with the secretory microcilli confined to the apical surface of the cell. Note that electron-dense material, visible in the gland lumen, is embedded in the microvilli. D: The most highly developed parietal cell observed in mutant stomachs showed membranes with secretory microvilli extending from the apical surface into the cytoplasm to form a short canaliculus. C, canaliculi; N, nucleus; MV, microvilli; L, lumen; BM, basal membrane; JC, junctional complex. Scale bars: A and B, 2um; C and D, 5um.

Copyright

This image is from Gawenis LR, J Biol Chem 2004 Jul 16;279(29):30531-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:91617

Associated Alleles

Symbol	Name
Slc4a2^tm1Ges	solute carrier family 4 (anion exchanger), member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc4a2^tm1Ges/Slc4a2^tm1Ges	involves: 129S6/SvEvTac * Black Swiss