Phenotype Image Detail

Image

Caption

A: Photograph of an Itgb6^tm1Des/Itgb6^tm1Des (left) mouse and a wild type (right) littermate at 10 days of age. In contrast to the wild type mouse, the homozygous mouse demonstrates the typical pattern of juvenile baldness over the head and neck. Homozygous mice also lack hair over the inside of their thighs. B and C: Low power photomicrographs of sections of frozen inner thigh skin from wild type (B) and mutant (C) mice stained with hematoxylin and eosin, demonstrate loss of hair follicles and infiltration of the dermis in the mutant mouse. D and E: Higher power photomicrographs of frozen sections of skin from the same areas of the same wild type (D) or mutant (E) mouse stained with the monocyte/macrophage marker F4/80, and lightly counterstained with hematoxylin and eosin. Hair follicles are marked with arrows. Infiltrating macrophages are marked with arrowheads. Note the marked increase in F4/80 positive cells in the mutant mouse.

Copyright

This image is from Huang XZ, J Cell Biol 1996 May;133(4):921-8, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:33139

Associated Alleles

Symbol	Name
Itgb6^tm1Des	integrin beta 6; targeted mutation 1, Dean Sheppard

Associated Genotypes

Allelic Composition	Genetic Background
Itgb6^tm1Des/Itgb6^tm1Des	involves: 129S4/SvJae * C57BL/6J