Phenotype Image Detail

Image

Caption

Hart stains of the ascending (A and B) and descending (C-F) aortae in wild type (+/+, A,C and E) and Eln^tm1Dyl/Eln⁺ (+/-, B, D and F) mice. Cross-sections are at the level where the pulmonary artery courses behind the ascending aorta. In this example there are 8 and 6 elastic lamellae in the ascending and descending aortae of the wild type mouse, respectively, compared with 11 and 8 in the heterozygous mutant mouse, respectively, indicating an inverse retlationship between Eln expression and the number of elastic lamellae. Lower magnification of the descending aortae (E and F) demonstrates that the inner and outer diameters of wild type and mutant aortae are similar.

Copyright

This image is from Li DY, J Clin Invest 1998 Nov 15;102(10):1783-7 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:51109

Associated Alleles

Symbol	Name
Eln^tm1Dyl	elastin; targeted mutation 1, Dean Y Li

Associated Genotypes

Allelic Composition	Genetic Background
Eln^tm1Dyl/Eln^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J