Phenotype Image Detail

Image

Caption

Characterization of E14.5 dpc F7^tm1Pec/F7^tm1Pec Proc^tm1Fjc/Proc^tm1Fjc mice. A: Gross appearance of an embryo. The hemorrhagic phenotype observed at E17.5 dpc is readily occurring at E14.5 dpc. Bleeding can be observed along the spinal column, in the brain, and in peripheral regions such as the snout. B-E: Histological analyses of whole sectioned embryos. Hemorrhage (b) and fibrin deposition (c) are seen in the snout, plus bleeding in the lateral ventricle (d) and behind the spinal column (e).

Copyright

This image is from Chan JC, J Clin Invest 2000 Apr;105(7):897-903 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61481

Associated Alleles

Symbol	Name
F7^tm1Pec	coagulation factor VII; targeted mutation 1, Peter Carmeliet
Proc^tm1Fjc	protein C; targeted mutation 1, Francis J Castellino

Associated Genotypes

Allelic Composition	Genetic Background
F7^tm1Pec/F7^tm1Pec Proc^tm1Fjc/Proc^tm1Fjc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6