Phenotype Image Detail

Image

Caption

A-E: Levels of plasma triglycerides (A), free fatty acids (B), cholesterol (C), glucose (D), and insulin (E) in matched, 6-h-fasted wild type (white bars; n=6-10) and Pparg^tm2(tTA)Yba/Pparg⁺ mice (black bars; n=6-10). Values are presented for 4 week old females and a longitudinal analysis of males aged 4-12 weeks. Asterisks designate statistically significant differences (P<0.05) between mutant and wild type mice. F and G: Pancreatic islet hyperplasia in mutant mice. H: Severe glucose intolerance in mutant (n = 5) as compared with wild type (n = 5). I: Hepatomegaly in mutant mice. J and K: Hepatic histology of wild type and mutant mice. Mutant hepatocytes are hypertrophic, and contain large unstained vacuoles, but do not display the prototypic lipid droplet accumulation of steatotic livers. L and M: Dox treatment circumvents hypertriglyceridemia and hyperinsulinemia in mutant mice. Values were measured in untreated 5.5 week old wild type and mutant mice (-) compared with matched mice exposed to dox from midgestation onwards (+). N: Aldehyde Fuchsin-stained pancreas from a 16 month old mutant male demonstrates rich insulin content in beta-cells of aged mutants. Tissue specimens were collected from 10 week old male mice, except in N. Scale bars: F, G and N, 100um; I, 1cm; J and K, 50um.

Copyright

This image is from Kim S, Proc Natl Acad Sci U S A 2007 Oct 16;104(42):16627-32. Copyright 2007 National Academy of Sciences, U.S.A. J:125992

Associated Alleles

Symbol	Name
Pparg^tm2(tTA)Yba	peroxisome proliferator activated receptor gamma; targeted mutation 2, Yaacob Barak

Associated Genotypes

Allelic Composition	Genetic Background
Pparg^tm2(tTA)Yba/Pparg^+	involves: 129S1/SvImJ * C57BL/6