Phenotype Image Detail

Image

Caption

A: Wild-type and Sirt1^tm1Fwa/Sirt1^tm1Fwa embryos at E16.5. * indicates exencephaly in the homozygous embryo. B: Whole mouse eyes from E16.5 embryos. Arrow indicates open optic tissue in the homozygous mouse eye. C: Retinal sections from 5 week old mice. Rosette-like structure. D: An elargement of (C). E: Retinal sections from E18.5 wild-type and homozygous embryos. F: Sections through E18.5 hearts. * indicates the VSD. G: Section through E18.5 homozygous heart showing elongated atrioventricular valve (arrow> Abbreviations: ganglion cell layer (gl); inner plexiform layer (ipl) inner nuclear layer (inl); outer plexiform layer (opl); outer nuclear layer (onl); inner segment (is); outer segment (os); pigmented epithelium (pe); left ventricle (LV); right ventricle (RV).

Copyright

This image is from Cheng HL, Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10794-9. Copyright 2003 National Academy of Sciences, U.S.A. J:85542

Associated Alleles

Symbol	Name
Sirt1^tm1Fwa	sirtuin 1; targeted mutation 1, Frederick W Alt

Associated Genotypes

Allelic Composition	Genetic Background
Sirt1^tm1Fwa/Sirt1^tm1Fwa	involves: 129/Sv * 129S6/SvEvTac