Gene Expression Image Detail

Reference

Figure

ID

J:41878 Zoltewicz JS, et al., Development. 1999 Nov;126(22):5085-95

6

MGI:1346353

Image

Caption

Compound heterozygotes sometimes have defects in anterior forebrain development that are indistinguishable from those of oto homozygotes. A dorsal view of Emx2 expression in the telencephalon of wild-type (A) and oto/+; Lim1 knockout/+ (B) embryos at 8.5 dpc shows a reduction of the telencephalic region, with a right-sided bias identical to defects that are seen in oto homozygotes. The blue arrowheads in C-J indicate diencephalic expression and the red arrowheads indicate telencephalic expression of Nkx2.1 inembryos at 9.5 dpc. Wild-type embryo (C,D). (F) oto/+; Lim1 knockout/+ embryo displaying a novel phenotype in the form of an anterior reduction in staining for Nkx2.1 in the ventral telencephalon. oto/oto; Lim1 knockout/+ exhibit an obviously novel phenotype - hypoplasia of the anterior-venetral diencephalon (G-J).

Copyright

This image is from Zoltewicz et al., Development 126:5085-5095 (1999), and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
A	MGI:1346418 (Emx2)
B	MGI:1346418 (Emx2)
C	MGI:1346416 (Nkx2-1)
D	MGI:1346416 (Nkx2-1)
E	MGI:1346416 (Nkx2-1)
F	MGI:1346416 (Nkx2-1)
G	MGI:1346416 (Nkx2-1)
H	MGI:1346416 (Nkx2-1)
I	MGI:1346416 (Nkx2-1)
J	MGI:1346416 (Nkx2-1)