Gene Expression Image Detail

Reference

Figure

ID

J:45709 Melloy PG, et al., Dev Biol. 1998 Jan 1;193(1):77-89

3

MGI:1343270

Image

Caption

At E8.5, nt embryos (C,D) are smaler in size and exhibit a grainy overall appearance compared to normal littermates (A,B) at the same somite stage of development. Note the reduced size of the head, especially in the frontonasal region (f). Also striking is the smaller size of the somites (s) in nt embryos (compare somites in B vs D). The neural folds along the entire craniocaudal axis of the nt embryo are wide open (see white arrows in D). In contrast, neural tube closure is almost complete in the normal littermate (except over the midbrain/anterior hindbrain; B). In this nt embryo, heart looping is reversed from that seen in the normal embryo (compare ht in C vs A). (H,I) f, forebrain; m, midbrain. (J) Note the reduced size of somites, and their irregular shape in the nt embryo as compared to the normal embryo (G). Scale bar, 500 mm. All images are at the same magnification.

Copyright

Reprinted with permission from Elsevier from doi:10.1006/dbio.1997.8787 Dev Biol 193: 77-89, Melloy PG; Ewart JL; Cohen MF; Desmond ME; Kuehn MR; Lo CW, No turning, a mouse mutation causing left-right and axial patterning defects. Copyright 1998

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
E	MGI:1343293 (Otx2)
F	MGI:1343293 (Otx2)
G	MGI:1343294 (Tcf15)
H	MGI:1343293 (Otx2)
I	MGI:1343293 (Otx2)
J	MGI:1343294 (Tcf15)