Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SCN5A	HGNC:10593 (HGNC) 6331 (Entrez Gene) 600163 (OMIM) SCN5A (Alliance of Genome Resources)	Chr3 p22.2	Chr3:38548057-38649687 (-) GRCh38	Brugada syndrome 1 dilated cardiomyopathy 1E familial atrial fibrillation long QT syndrome long QT syndrome 3 progressive familial heart block type IA sick sinus syndrome sudden infant death syndrome	Q14524 (UniProt | EBI) NM_001407186 (RefSeq)
mouse	Scn5a	MGI:98251 (MGI) 20271 (Entrez Gene) Gene Tree Scn5a (Alliance of Genome Resources)	Chr9 71.33 cM	Chr9:119312474-119408082 (-) GRCm39	Brugada syndrome 1 long QT syndrome 3 progressive familial heart block type IA sick sinus syndrome	ENSMUSG00000032511 (Ensembl Gene Model) ENSMUSP00000112838 (Ensembl) ENSMUST00000117911 (Ensembl)
rat	Scn5a	RGD:3637 (Rat Genome Database) 25665 (Entrez Gene) Scn5a (Alliance of Genome Resources)	Chr8 q32			P15389 (UniProt | EBI) NM_013125 (RefSeq)
zebrafish	scn5lab	ZDB-GENE-060908-3 (Zebrafish Model Organism Database) 566868 (Entrez Gene) scn5lab (Alliance of Genome Resources)	Chr24			NP_001038588 (RefSeq) NM_001045123 (RefSeq)
	scn12aa	ZDB-GENE-060908-2 (Zebrafish Model Organism Database) 795688 (Entrez Gene) scn12aa (Alliance of Genome Resources)	Chr2			NP_001038387 (RefSeq) NM_001044922 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.