Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SIX6	HGNC:10892 (HGNC) 4990 (Entrez Gene) 606326 (OMIM) SIX6 (Alliance of Genome Resources)	Chr14 q23.1	Chr14:60509146-60512850 (+) GRCh38	optic disc anomalies with retinal and/or macular dystrophy	O95475 (UniProt | EBI) NM_007374 (RefSeq)
mouse	Six6	MGI:1341840 (MGI) 20476 (Entrez Gene) Gene Tree Six6 (Alliance of Genome Resources)	Chr12 30.31 cM	Chr12:72986666-72991673 (+) GRCm39		ENSMUSG00000021099 (Ensembl Gene Model) ENSMUSP00000021519 (Ensembl) ENSMUST00000021519 (Ensembl)
rat	Six6	RGD:1310497 (Rat Genome Database) 314221 (Entrez Gene) Six6 (Alliance of Genome Resources)	Chr6 q24			NP_001101502 (RefSeq) NM_001108032 (RefSeq)
zebrafish	six6a	ZDB-GENE-040426-1282 (Zebrafish Model Organism Database) 394080 (Entrez Gene) six6a (Alliance of Genome Resources)	Chr13			NP_957399 (RefSeq) NM_201105 (RefSeq)
	six6b	ZDB-GENE-050522-308 (Zebrafish Model Organism Database) 553611 (Entrez Gene) six6b (Alliance of Genome Resources)	Chr20			NP_001018421 (RefSeq) NM_001020585 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.