Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	DYRK1A	HGNC:3091 (HGNC) 1859 (Entrez Gene) 600855 (OMIM) DYRK1A (Alliance of Genome Resources)	Chr21 q22.13	Chr21:37365573-37526358 (+) GRCh38	autism spectrum disorder autosomal dominant intellectual developmental disorder 7 intellectual disability	Q13627 (UniProt | EBI) NM_001396 (RefSeq)
mouse	Dyrk1a	MGI:1330299 (MGI) 13548 (Entrez Gene) Gene Tree Dyrk1a (Alliance of Genome Resources)	Chr16 55.3 cM	Chr16:94370869-94496376 (+) GRCm39	autosomal dominant intellectual developmental disorder 7 Down syndrome	ENSMUSG00000022897 (Ensembl Gene Model) ENSMUSP00000023614 (Ensembl) ENSMUST00000023614 (Ensembl)
rat	Dyrk1a	RGD:2528 (Rat Genome Database) 25255 (Entrez Gene) Dyrk1a (Alliance of Genome Resources)	Chr11 q11			Q63470 (UniProt | EBI) NM_012791 (RefSeq)
zebrafish	dyrk1aa	ZDB-GENE-050302-29 (Zebrafish Model Organism Database) 100005019 (Entrez Gene) dyrk1aa (Alliance of Genome Resources)	Chr10			NP_001074158 (RefSeq) NM_001080689 (RefSeq)
	dyrk1ab	ZDB-GENE-030131-5677 (Zebrafish Model Organism Database) 327466 (Entrez Gene) dyrk1ab (Alliance of Genome Resources)	Chr15			NP_001334760 (RefSeq) NM_001347831 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.