Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PSEN2	HGNC:9509 (HGNC) 5664 (Entrez Gene) 600759 (OMIM) PSEN2 (Alliance of Genome Resources)	Chr1 q42.13	Chr1:226870184-226927726 (+) GRCh38	Alzheimer's disease Alzheimer's disease 4 breast cancer dilated cardiomyopathy 1V	P49810 (UniProt | EBI) NM_012486 (RefSeq)
mouse	Psen2	MGI:109284 (MGI) 19165 (Entrez Gene) Gene Tree Psen2 (Alliance of Genome Resources)	Chr1 84.19 cM	Chr1:180054569-180091003 (-) GRCm39		ENSMUSG00000010609 (Ensembl Gene Model) ENSMUSP00000106735 (Ensembl) ENSMUST00000111106 (Ensembl)
rat	Psen2	RGD:621060 (Rat Genome Database) 81751 (Entrez Gene) Psen2 (Alliance of Genome Resources)	Chr13 q26			O88777 (UniProt | EBI) NM_031087 (RefSeq)
zebrafish	psen2	ZDB-GENE-000330-9 (Zebrafish Model Organism Database) 58026 (Entrez Gene) psen2 (Alliance of Genome Resources)	Chr1			Q90ZE4 (UniProt | EBI) NM_131514 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.