Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes YTHDC2
  • Mouse genes Ythdc2
  • Rat genes Ythdc2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ythdc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034458	3'-5' RNA helicase activity	YTHDC2	IDA		Human	PMID:29033321
Molecular Function	GO:0034458	3'-5' RNA helicase activity	Ythdc2	IDA		Mouse	MGI:MGI:6113138|PMID:29360036
Molecular Function	GO:0008186	ATP-dependent activity, acting on RNA	YTHDC2	IDA		Human	PMID:21559518
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA binding	YTHDC2	IDA		Human	PMID:26318451
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA binding	YTHDC2	IDA		Human	PMID:28809393
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA binding	YTHDC2	IDA		Human	PMID:29033321
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA binding	Ythdc2	IDA		Mouse	MGI:MGI:5911611|PMID:28809393
Molecular Function	GO:0005515	protein binding	YTHDC2	IPI	UniProtKB:Q15306	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	YTHDC2	IPI	UniProtKB:Q99J34	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	YTHDC2	IPI	UniProtKB:A2AG06	Human	PMID:26742488
Molecular Function	GO:0005515	protein binding	YTHDC2	IPI	UniProtKB:Q8IZH2	Human	PMID:29033321
Molecular Function	GO:0005515	protein binding	Ythdc2	IPI	UniProtKB:A2AG06	Mouse	MGI:MGI:5905073|PMID:28380054
Molecular Function	GO:0005515	protein binding	Ythdc2	IPI	UniProtKB:A2AG06	Mouse	MGI:MGI:5770021|PMID:26742488
Molecular Function	GO:0005515	protein binding	Ythdc2	IPI	UniProtKB:A2AG06|UniProtKB:P97789	Mouse	MGI:MGI:5911610|PMID:29033321
Molecular Function	GO:0003723	RNA binding	YTHDC2	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	YTHDC2	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	Ythdc2	IDA		Mouse	MGI:MGI:6109052|PMID:29087293
Molecular Function	GO:0070063	RNA polymerase binding	YTHDC2	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:21559518
Cellular Component	GO:0005737	cytoplasm	Ythdc2	IDA		Mouse	MGI:MGI:5905073|PMID:28380054
Cellular Component	GO:0005737	cytoplasm	Ythdc2	IDA		Mouse	MGI:MGI:6109052|PMID:29087293
Cellular Component	GO:0005737	cytoplasm	Ythdc2	IDA		Mouse	MGI:MGI:5911610|PMID:29033321
Cellular Component	GO:0005737	cytoplasm	Ythdc2	IDA		Mouse	MGI:MGI:6113138|PMID:29360036
Cellular Component	GO:0005783	endoplasmic reticulum	YTHDC2	IDA		Human	PMID:21559518
Cellular Component	GO:0035770	ribonucleoprotein granule	Ythdc2	IDA		Mouse	MGI:MGI:6109052|PMID:29087293
Biological Process	GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle	Ythdc2	IMP		Mouse	MGI:MGI:5911610|PMID:29033321
Biological Process	GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle	Ythdc2	IMP		Mouse	MGI:MGI:6113138|PMID:29360036
Biological Process	GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle	Ythdc2	IMP		Mouse	MGI:MGI:6109052|PMID:29087293
Biological Process	GO:0048599	oocyte development	Ythdc2	IMP		Mouse	MGI:MGI:5911610|PMID:29033321
Biological Process	GO:0048599	oocyte development	Ythdc2	IMP		Mouse	MGI:MGI:6453582|PMID:32470506
Biological Process	GO:0048599	oocyte development	Ythdc2	IMP		Mouse	MGI:MGI:6109052|PMID:29087293
Biological Process	GO:0048599	oocyte development	Ythdc2	IMP		Mouse	MGI:MGI:6113138|PMID:29360036
Biological Process	GO:0044829	positive regulation by host of viral genome replication	YTHDC2	IMP		Human	PMID:21559518
Biological Process	GO:0070555	response to interleukin-1	YTHDC2	IDA		Human	PMID:21559518
Biological Process	GO:0034612	response to tumor necrosis factor	YTHDC2	IDA		Human	PMID:21559518
Biological Process	GO:0007286	spermatid development	Ythdc2	IMP		Mouse	MGI:MGI:6113138|PMID:29360036
Biological Process	GO:0007286	spermatid development	Ythdc2	IMP		Mouse	MGI:MGI:6109052|PMID:29087293
Biological Process	GO:0007286	spermatid development	Ythdc2	IMP		Mouse	MGI:MGI:5911610|PMID:29033321

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern