Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XRN2
  • Mouse genes Xrn2
  • Rat genes Xrn2
  • Zfish genes xrn2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xrn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000175	3'-5'-RNA exonuclease activity	XRN2	EXP		Human	PMID:23482395
Molecular Function	GO:0008409	5'-3' exonuclease activity	XRN2	IDA		Human	PMID:15565158
Molecular Function	GO:0042802	identical protein binding	XRN2	IPI	UniProtKB:Q9H0D6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q13148	Human	PMID:15231747
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q9NRI5	Human	PMID:17043677
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q2Q1W2	Human	PMID:23125361
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q14147	Human	PMID:25220460
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q96HQ2	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q9NXV6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:P24928	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q16637	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q96HQ2	Human	PMID:26779609
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q9NRI5	Human	PMID:29961565
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:P80188	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q49AN0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q5W5X9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q96HQ2	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	XRN2	IPI	UniProtKB:Q9NXV6	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Xrn2	IPI	PR:A2AKX3	Mouse	PMID:22767893
Molecular Function	GO:0003723	RNA binding	XRN2	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	XRN2	HDA		Human	PMID:22681889
Molecular Function	GO:0001147	transcription termination site sequence-specific DNA binding	XRN2	IDA		Human	PMID:21700224
Cellular Component	GO:0016235	aggresome	XRN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	XRN2	HDA		Human	PMID:19946888
Cellular Component	GO:0005730	nucleolus	XRN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	XRN2	IDA		Human	PMID:12429849
Cellular Component	GO:0005654	nucleoplasm	XRN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Xrn2	IDA		Rat	PMID:23933240|RGD:9684963
Biological Process	GO:0021766	hippocampus development	Xrn2	IEP		Rat	PMID:23933240|RGD:9684963
Biological Process	GO:0030182	neuron differentiation	Xrn2	IEP		Rat	PMID:23933240|RGD:9684963
Biological Process	GO:0060041	retina development in camera-type eye	Xrn2	IEP		Rat	PMID:23700402|RGD:11041783
Biological Process	GO:0016070	RNA metabolic process	Xrn2	IGI	UniProtKB:P40848	Mouse	MGI:MGI:71199|PMID:7885830
Biological Process	GO:0007283	spermatogenesis	XRN2	IEP		Human	PMID:10409438
Biological Process	GO:0007283	spermatogenesis	Xrn2	IEP		Mouse	MGI:MGI:71199|PMID:7885830
Biological Process	GO:0006369	termination of RNA polymerase II transcription	XRN2	IMP		Human	PMID:15565158

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern