Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UNC5B
  • Mouse genes Unc5b
  • Rat genes Unc5b
  • Zfish genes unc5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Unc5b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005042	netrin receptor activity	Unc5b	IDA		Rat	PMID:9126742|RGD:634450
Molecular Function	GO:0005515	protein binding	UNC5B	IPI	UniProtKB:Q8CGU4	Human	PMID:18469807
Molecular Function	GO:0005515	protein binding	UNC5B	IPI	UniProtKB:Q9NZU0	Human	PMID:26235030
Molecular Function	GO:0005515	protein binding	Unc5b	IPI	UniProtKB:Q7TNP2	Mouse	MGI:MGI:5298331|PMID:21172653
Molecular Function	GO:0005515	protein binding	Unc5b	IPI	UniProtKB:O09118	Mouse	MGI:MGI:5771592|PMID:26859457
Molecular Function	GO:0005515	protein binding	Unc5b	IPI	PR:Q8BGT1	Mouse	PMID:21673655
Molecular Function	GO:0005515	protein binding	Unc5b	IPI	UniProtKB:Q8CGU4	Rat	PMID:18469807|RGD:8553892
Molecular Function	GO:0005515	protein binding	Unc5b	IPI	UniProtKB:P30154	Rat	PMID:21172653|RGD:8554227
Molecular Function	GO:0005515	protein binding	unc5b	IPI	UniProtKB:A8BBF0	Zfish	PMID:19765300
Molecular Function	GO:0005515	protein binding	unc5b	IPI	UniProtKB:A8BBF4	Zfish	PMID:19765300
Molecular Function	GO:0005515	protein binding	unc5b	IPI	UniProtKB:A8BAV0	Zfish	PMID:19765300
Molecular Function	GO:0005515	protein binding	unc5b	IPI	UniProtKB:A8BBF9	Zfish	PMID:19765300
Cellular Component	GO:0045121	membrane raft	Unc5b	IDA		Rat	PMID:21172653|RGD:8554227
Biological Process	GO:0033564	anterior/posterior axon guidance	Unc5b	IMP		Mouse	PMID:18479186
Biological Process	GO:0007411	axon guidance	Unc5b	IGI	UniProtKB:B1H234	Rat	PMID:21673655|RGD:8554719
Biological Process	GO:0007411	axon guidance	Unc5b	IDA		Rat	PMID:9126742|RGD:634450
Biological Process	GO:0048514	blood vessel morphogenesis	unc5b	IMP	ZFIN:ZDB-MRPHLNO-080515-1	Zfish	PMID:20466982
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	unc5b	IMP		Zfish	PMID:15510105
Biological Process	GO:0016525	negative regulation of angiogenesis	unc5b	IMP		Zfish	PMID:15510105
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	UNC5B	IMP		Human	PMID:18469807
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	UNC5B	IMP		Human	PMID:18469807
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	Unc5b	IMP		Rat	PMID:21172653|RGD:8554227
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	UNC5B	IMP		Human	PMID:18469807

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern