Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TUBB4B
  • Mouse genes Tubb4b
  • Rat genes Tubb4b
  • Zfish genes tubb2b,tubb4b,zgc:55461
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tubb4b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	TUBB4B	IDA		Human	PMID:21266579
Molecular Function	GO:0005515	protein binding	TUBB4B	IPI	UniProtKB:Q5S007	Human	PMID:24275654
Molecular Function	GO:0005515	protein binding	TUBB4B	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	Tubb4b	IPI	UniProtKB:Q9R0N3	Rat	PMID:24882364|RGD:8693368
Cellular Component	GO:0070062	extracellular exosome	TUBB4B	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	TUBB4B	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	TUBB4B	HDA		Human	PMID:23533145
Cellular Component	GO:1903561	extracellular vesicle	TUBB4B	HDA		Human	PMID:24769233
Cellular Component	GO:0045171	intercellular bridge	TUBB4B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005874	microtubule	TUBB4B	IDA		Human	PMID:21525035
Cellular Component	GO:0015630	microtubule cytoskeleton	TUBB4B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	TUBB4B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043209	myelin sheath	Tubb4b	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	TUBB4B	HDA		Human	PMID:21630459
Biological Process	GO:0060271	cilium assembly	tubb4b	IMP	ZFIN:ZDB-MRPHLNO-170127-22	Zfish	PMID:27903883
Biological Process	GO:0060271	cilium assembly	tubb4b	IMP	ZFIN:ZDB-MRPHLNO-170127-21	Zfish	PMID:27903883

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern