Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPC5
  • Mouse genes Trpc5
  • Rat genes Trpc5
  • Zfish genes trpc5a,trpc5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Trpc5	IDA		Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0042805	actinin binding	Trpc5	IDA		Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0051117	ATPase binding	Trpc5	IPI	RGD:2169	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0005262	calcium channel activity	TRPC5	IDA		Human	PMID:20164195
Molecular Function	GO:0030276	clathrin binding	Trpc5	IDA		Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	Trpc5	IDA		Mouse	MGI:MGI:3525624|PMID:14505576
Molecular Function	GO:0005515	protein binding	TRPC5	IPI	UniProtKB:Q86VW0	Human	PMID:20164195
Molecular Function	GO:0005515	protein binding	TRPC5	IPI	UniProtKB:O15162	Human	PMID:32110987
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	UniProtKB:Q86YM7	Mouse	MGI:MGI:3525624|PMID:14505576
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	UniProtKB:Q9JJ00	Mouse	MGI:MGI:6450314|PMID:32110987
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	PR:Q6SP97	Mouse	PMID:15385169
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:61973	Rat	PMID:12857742|RGD:10043836
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:619783	Rat	PMID:12857742|RGD:10043836
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:619788	Rat	PMID:12857742|RGD:10043836
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:68947	Rat	PMID:12858178|RGD:1304405
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:632280	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:632281	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:70885	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:71096	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0005515	protein binding	Trpc5	IPI	RGD:3347|RGD:3214	Rat	PMID:22764246|RGD:10044012
Cellular Component	GO:0034704	calcium channel complex	TRPC5	IDA		Human	PMID:20164195
Cellular Component	GO:0005737	cytoplasm	Trpc5	IDA		Rat	PMID:21179559|RGD:10043832
Cellular Component	GO:0030425	dendrite	Trpc5	IDA		Rat	PMID:22764246|RGD:10044012
Cellular Component	GO:0030426	growth cone	Trpc5	IDA		Rat	PMID:12858178|RGD:1304405
Cellular Component	GO:0045121	membrane raft	Trpc5	IDA		Rat	PMID:19657032|RGD:10044013
Cellular Component	GO:0043025	neuronal cell body	Trpc5	IDA		Rat	PMID:22764246|RGD:10044012
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	Trpc5	IMP		Rat	PMID:22764246|RGD:10044012
Biological Process	GO:0051402	neuron apoptotic process	Trpc5	IMP		Mouse	MGI:MGI:6450314|PMID:32110987
Biological Process	GO:0030182	neuron differentiation	Trpc5	IEP		Rat	PMID:21618530|RGD:7495774
Biological Process	GO:0070782	phosphatidylserine exposure on apoptotic cell surface	Trpc5	IMP		Mouse	MGI:MGI:6450314|PMID:32110987
Biological Process	GO:0045773	positive regulation of axon extension	Trpc5	IMP		Rat	PMID:21984481|RGD:10043835
Biological Process	GO:0008284	positive regulation of cell population proliferation	Trpc5	IMP		Rat	PMID:21984481|RGD:10043835
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Trpc5	IMP		Rat	PMID:22764246|RGD:10044012
Biological Process	GO:0045666	positive regulation of neuron differentiation	Trpc5	IMP		Rat	PMID:20479868|RGD:10044014
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Trpc5	IMP		Rat	PMID:22699894|RGD:10044018
Biological Process	GO:1902630	regulation of membrane hyperpolarization	Trpc5	IMP		Rat	PMID:21179559|RGD:10043832

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern