Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPC4
  • Mouse genes Trpc4
  • Rat genes Trpc4
  • Zfish genes trpc4a,trpc4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	TRPC4	IPI	UniProtKB:P35222	Human	PMID:19996314
Molecular Function	GO:0045296	cadherin binding	TRPC4	IPI	UniProtKB:P33151	Human	PMID:19996314
Molecular Function	GO:0005262	calcium channel activity	Trpc4	IDA		Rat	PMID:11713258|RGD:625475
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	Trpc4	IDA		Mouse	MGI:MGI:3525624|PMID:14505576
Molecular Function	GO:0005261	monoatomic cation channel activity	trpc4b	IDA		Zfish	PMID:29717981
Molecular Function	GO:0005515	protein binding	TRPC4	IPI	UniProtKB:P20591	Human	PMID:15757897
Molecular Function	GO:0005515	protein binding	TRPC4	IPI	UniProtKB:P11171	Human	PMID:16254212
Molecular Function	GO:0005515	protein binding	TRPC4	IPI	UniProtKB:Q86VW0	Human	PMID:20164195
Molecular Function	GO:0005515	protein binding	Trpc4	IPI	UniProtKB:Q9JJ00	Mouse	MGI:MGI:6450314|PMID:32110987
Molecular Function	GO:0005515	protein binding	Trpc4	IPI	PR:P16546	Mouse	PMID:18796539
Molecular Function	GO:0005515	protein binding	Trpc4	IPI	PR:Q61056	Mouse	PMID:17416589
Molecular Function	GO:0005515	protein binding	Trpc4	IPI	PR:P11881	Mouse	PMID:17416589
Molecular Function	GO:0005515	protein binding	Trpc4	IPI	PR:P49817	Mouse	PMID:17416589
Molecular Function	GO:0015279	store-operated calcium channel activity	TRPC4	IMP		Human	PMID:16254212
Cellular Component	GO:0016323	basolateral plasma membrane	TRPC4	IDA		Human	PMID:19996314
Cellular Component	GO:0034704	calcium channel complex	TRPC4	IDA		Human	PMID:20164195
Cellular Component	GO:0005901	caveola	Trpc4	IDA		Mouse	PMID:11897792
Cellular Component	GO:0009986	cell surface	TRPC4	IDA		Human	PMID:19996314
Cellular Component	GO:0005911	cell-cell junction	TRPC4	IDA		Human	PMID:19996314
Cellular Component	GO:0030863	cortical cytoskeleton	TRPC4	IDA		Human	PMID:16254212
Cellular Component	GO:0005737	cytoplasm	Trpc4	IDA		Rat	PMID:12381092|RGD:730206
Cellular Component	GO:0045121	membrane raft	Trpc4	IDA		Mouse	PMID:17416589
Cellular Component	GO:0005886	plasma membrane	TRPC4	IDA		Human	PMID:16254212
Cellular Component	GO:0005886	plasma membrane	Trpc4	IDA		Mouse	MGI:MGI:3525624|PMID:14505576
Cellular Component	GO:0005886	plasma membrane	Trpc4	IDA		Mouse	PMID:10998353
Cellular Component	GO:0005886	plasma membrane	Trpc4	IDA		Rat	PMID:11713258|RGD:625475
Cellular Component	GO:0005886	plasma membrane	Trpc4	IDA		Rat	PMID:12381092|RGD:730206
Cellular Component	GO:0005886	plasma membrane	trpc4b	IDA		Zfish	PMID:29717981
Cellular Component	GO:0032991	protein-containing complex	Trpc4	IPI	PR:P11881	Mouse	PMID:17416589
Cellular Component	GO:0032991	protein-containing complex	Trpc4	IPI	PR:Q61056	Mouse	PMID:17416589
Cellular Component	GO:0032991	protein-containing complex	Trpc4	IPI	PR:P49817	Mouse	PMID:17416589
Biological Process	GO:0070509	calcium ion import	TRPC4	IDA		Human	PMID:19996314
Biological Process	GO:0006816	calcium ion transport	Trpc4	IDA		Rat	PMID:11713258|RGD:625475
Biological Process	GO:0014051	gamma-aminobutyric acid secretion	Trpc4	IMP	MGI:MGI:2387666	Mouse	PMID:14668438
Biological Process	GO:0098655	monoatomic cation transmembrane transport	trpc4b	IDA		Zfish	PMID:29717981|ZFIN:ZDB-PUB-180503-4
Biological Process	GO:0006812	monoatomic cation transport	trpc4b	IDA		Zfish	PMID:29717981
Biological Process	GO:0048709	oligodendrocyte differentiation	Trpc4	IMP		Mouse	PMID:19139271
Biological Process	GO:0106129	positive regulation of store-operated calcium entry	Trpc4	IMP		Rat	PMID:24113457|RGD:150429956
Biological Process	GO:0099605	regulation of action potential firing rate	Trpc4	IMP		Rat	PMID:26988269|RGD:126848803
Biological Process	GO:0051924	regulation of calcium ion transport	Trpc4	IMP		Rat	PMID:12381092|RGD:730206

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern