Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPC3
  • Mouse genes Trpc3
  • Rat genes Trpc3
  • Zfish genes trpc3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005227	calcium activated cation channel activity	Trpc3	IDA		Rat	PMID:10984475|RGD:61774
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	TRPC3	IDA		Human	PMID:14505576
Molecular Function	GO:0005515	protein binding	TRPC3	IPI	UniProtKB:Q14573	Human	PMID:10611319
Molecular Function	GO:0005515	protein binding	TRPC3	IPI	UniProtKB:P10686	Human	PMID:15744307
Molecular Function	GO:0005515	protein binding	TRPC3	IPI	UniProtKB:P20591	Human	PMID:15757897
Molecular Function	GO:0005515	protein binding	TRPC3	IPI	UniProtKB:Q96D31	Human	PMID:17360584
Molecular Function	GO:0005515	protein binding	TRPC3	IPI	UniProtKB:Q9BR39	Human	PMID:20095964
Molecular Function	GO:0005515	protein binding	Trpc3	IPI	UniProtKB:Q13563	Mouse	MGI:MGI:6810689|PMID:19812035
Cellular Component	GO:0005886	plasma membrane	TRPC3	IDA		Human	PMID:9368034
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPC3	IDA		Human	PMID:21062895
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	TRPC3	IDA		Human	PMID:21062895
Biological Process	GO:1903244	positive regulation of cardiac muscle hypertrophy in response to stress	TRPC3	IDA		Human	PMID:19287093
Biological Process	GO:0033198	response to ATP	TRPC3	IDA		Human	PMID:21062895
Biological Process	GO:0051592	response to calcium ion	TRPC3	IDA		Human	PMID:21062895

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern