Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPM4
  • Mouse genes Tpm4
  • Rat genes Tpm4
  • Zfish genes tpm4a,tpm4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tpm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Tpm4	IDA		Mouse	PMID:16765662
Molecular Function	GO:0051015	actin filament binding	Tpm4	IDA		Rat	PMID:7568216|RGD:12911000
Molecular Function	GO:0042802	identical protein binding	Tpm4	IDA		Rat	PMID:7568216|RGD:12911000
Molecular Function	GO:0005515	protein binding	TPM4	IPI	UniProtKB:Q9ULZ3	Human	PMID:24407287
Molecular Function	GO:0005515	protein binding	TPM4	IPI	UniProtKB:O75564-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TPM4	IPI	UniProtKB:O95295	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TPM4	IPI	UniProtKB:P06753	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TPM4	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0046982	protein heterodimerization activity	Tpm4	IDA		Rat	PMID:7568216|RGD:12911000
Molecular Function	GO:0042803	protein homodimerization activity	Tpm4	IDA		Rat	PMID:7568216|RGD:12911000
Cellular Component	GO:0015629	actin cytoskeleton	Tpm4	IDA		Rat	PMID:7568216|RGD:12911000
Cellular Component	GO:0030863	cortical cytoskeleton	Tpm4	IDA		Mouse	PMID:16765662
Cellular Component	GO:0005737	cytoplasm	Tpm4	IDA		Mouse	PMID:16765662
Cellular Component	GO:0070062	extracellular exosome	TPM4	HDA		Human	PMID:20458337
Cellular Component	GO:0005925	focal adhesion	TPM4	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	TPM4	HDA		Human	PMID:16210410
Cellular Component	GO:0002102	podosome	Tpm4	IDA		Mouse	PMID:16765662
Cellular Component	GO:0001725	stress fiber	TPM4	IDA		Human	PMID:16236705
Biological Process	GO:0060048	cardiac muscle contraction	tpm4a	IMP	ZFIN:ZDB-GENO-090820-5	Zfish	PMID:18583338
Biological Process	GO:0055003	cardiac myofibril assembly	tpm4a	IMP	ZFIN:ZDB-GENO-090820-5	Zfish	PMID:18583338
Biological Process	GO:0060047	heart contraction	tpm4a	IMP	ZFIN:ZDB-MRPHLNO-090729-5	Zfish	PMID:19800866
Biological Process	GO:0001649	osteoblast differentiation	TPM4	HDA		Human	PMID:16210410

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern