Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM88
  • Mouse genes Tmem88
  • Rat genes Tmem88
  • Zfish genes tmem88a,tmem88b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem88

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030165	PDZ domain binding	Tmem88	IDA		Mouse	MGI:MGI:5437424|PMID:21044957
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:P51141	Human	PMID:26359454
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:Q92997	Human	PMID:26359454
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:A2RU14	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:O14523	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:O14925	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:P04921	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:P17152	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:P56557	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:Q16617	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:Q86Y07	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:Q8N966	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:Q9BXJ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM88	IPI	UniProtKB:Q9GZY8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tmem88	IPI	UniProtKB:P51141	Mouse	MGI:MGI:5437424|PMID:21044957
Cellular Component	GO:0005829	cytosol	TMEM88	IDA		Human	PMID:26359454
Cellular Component	GO:0005886	plasma membrane	TMEM88	IDA		Human	PMID:21044957
Cellular Component	GO:0005886	plasma membrane	TMEM88	IDA		Human	PMID:26359454
Biological Process	GO:0030099	myeloid cell differentiation	tmem88a	IMP	ZFIN:ZDB-MRPHLNO-130410-7	Zfish	PMID:23072875
Biological Process	GO:0030099	myeloid cell differentiation	tmem88a	IMP	ZFIN:ZDB-MRPHLNO-130410-8	Zfish	PMID:23072875
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	TMEM88	IMP		Human	PMID:21044957
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	TMEM88	IDA		Human	PMID:26359454
Biological Process	GO:1901296	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	tmem88a	IMP	ZFIN:ZDB-MRPHLNO-131101-1,ZFIN:ZDB-MRPHLNO-131101-2	Zfish	PMID:23903195
Biological Process	GO:0060215	primitive hemopoiesis	tmem88a	IMP	ZFIN:ZDB-MRPHLNO-130410-7	Zfish	PMID:23072875
Biological Process	GO:0060215	primitive hemopoiesis	tmem88a	IMP	ZFIN:ZDB-MRPHLNO-130410-8	Zfish	PMID:23072875
Biological Process	GO:0072659	protein localization to plasma membrane	TMEM88	IGI	UniProtKB:P51142	Human	PMID:21044957
Biological Process	GO:0050821	protein stabilization	TMEM88	IGI	UniProtKB:P51141|UniProtKB:Q92997	Human	PMID:26359454

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern