Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM106A
  • Mouse genes Tmem106a
  • Rat genes Tmem106a
  • Zfish genes tmem106a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem106a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:O14653	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:O14817	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:O75355-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:P24593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:P29033	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:Q5BJH2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:Q6UX40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:Q9BVX2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:Q9H2S6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106A	IPI	UniProtKB:Q9UKR5	Human	PMID:32296183
Cellular Component	GO:0005886	plasma membrane	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0035780	CD80 biosynthetic process	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0035781	CD86 biosynthetic process	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0042116	macrophage activation	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0043410	positive regulation of MAPK cascade	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:1904407	positive regulation of nitric oxide metabolic process	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tmem106a	IDA		Mouse	MGI:MGI:6216178|PMID:26215746

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern