Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TM6SF2
  • Mouse genes Tm6sf2
  • Rat genes Tm6sf2
  • Zfish genes tm6sf2a,tm6sf2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tm6sf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TM6SF2	IPI	UniProtKB:Q9BZW4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:P15151	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:P31937	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:P48051	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:Q8WWF3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:Q9BXK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TM6SF2	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TM6SF2	IDA		Human	PMID:24927523
Cellular Component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TM6SF2	IDA		Human	PMID:24927523
Biological Process	GO:0055088	lipid homeostasis	tm6sf2b	IGI	ZFIN:ZDB-MRPHLNO-170719-1,ZFIN:ZDB-MRPHLNO-170719-2	Zfish	PMID:28027591
Biological Process	GO:0055088	lipid homeostasis	tm6sf2b	IMP	ZFIN:ZDB-MRPHLNO-170719-2	Zfish	PMID:28027591
Biological Process	GO:0055088	lipid homeostasis	tm6sf2b	IMP	ZFIN:ZDB-CRISPR-180321-1	Zfish	PMID:28027591
Biological Process	GO:0055088	lipid homeostasis	tm6sf2b	IMP	ZFIN:ZDB-CRISPR-180509-1	Zfish	PMID:28027591
Biological Process	GO:0055088	lipid homeostasis	tm6sf2b	IGI	ZFIN:ZDB-GENO-111222-39	Zfish	PMID:28027591
Biological Process	GO:0019216	regulation of lipid metabolic process	TM6SF2	IDA		Human	PMID:24927523
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	tm6sf2b	IGI	ZFIN:ZDB-MRPHLNO-170719-1,ZFIN:ZDB-MRPHLNO-170719-2	Zfish	PMID:28027591
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	tm6sf2b	IGI	ZFIN:ZDB-GENO-111222-39	Zfish	PMID:28027591
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	tm6sf2b	IMP	ZFIN:ZDB-MRPHLNO-170719-2	Zfish	PMID:28027591

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern