Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLR8
  • Mouse genes Tlr8
  • Rat genes Tlr8
  • Zfish genes tlr8a,tlr8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlr8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	TLR8	IDA		Human	PMID:16123302
Molecular Function	GO:0003725	double-stranded RNA binding	TLR8	IDA		Human	PMID:16111635
Molecular Function	GO:0003725	double-stranded RNA binding	TLR8	IDA		Human	PMID:33718825
Molecular Function	GO:0005515	protein binding	Tlr8	IPI	UniProtKB:P58242	Mouse	MGI:MGI:5689225|PMID:26095358
Molecular Function	GO:0003727	single-stranded RNA binding	TLR8	IDA		Human	PMID:14976262
Molecular Function	GO:0003727	single-stranded RNA binding	TLR8	IDA		Human	PMID:24942581
Cellular Component	GO:0009897	external side of plasma membrane	TLR8	IDA		Human	PMID:24942581
Biological Process	GO:0071260	cellular response to mechanical stimulus	TLR8	IEP		Human	PMID:19593445
Biological Process	GO:0051607	defense response to virus	TLR8	IMP		Human	PMID:16188996
Biological Process	GO:0051607	defense response to virus	TLR8	IEP		Human	PMID:32634389
Biological Process	GO:0051607	defense response to virus	TLR8	IDA		Human	PMID:33718825
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	TLR8	IDA		Human	PMID:12032557
Biological Process	GO:0032695	negative regulation of interleukin-12 production	TLR8	IDA		Human	PMID:24942581
Biological Process	GO:0045089	positive regulation of innate immune response	TLR8	IDA		Human	PMID:16123302
Biological Process	GO:0032727	positive regulation of interferon-alpha production	TLR8	IDA		Human	PMID:16286015
Biological Process	GO:0032728	positive regulation of interferon-beta production	TLR8	IDA		Human	PMID:16286015
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	TLR8	IDA		Human	PMID:24942581
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	TLR8	IDA		Human	PMID:33718825
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TLR8	IDA		Human	PMID:24942581
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR8	IMP		Human	PMID:16188996
Biological Process	GO:0032729	positive regulation of type II interferon production	TLR8	IDA		Human	PMID:16286015
Biological Process	GO:0001932	regulation of protein phosphorylation	Tlr8	IGI	MGI:MGI:2176882	Mouse	PMID:24740015
Biological Process	GO:0009615	response to virus	TLR8	IDA		Human	PMID:12032557
Biological Process	GO:0034158	toll-like receptor 8 signaling pathway	TLR8	IDA		Human	PMID:24942581
Biological Process	GO:0034158	toll-like receptor 8 signaling pathway	TLR8	IDA		Human	PMID:33718825

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern