Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLN1
  • Mouse genes Tln1
  • Rat genes Tln1
  • Zfish genes tln1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tln1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	TLN1	HDA		Human	PMID:25468996
Molecular Function	GO:0005178	integrin binding	TLN1	IPI	UniProtKB:P05556	Human	PMID:12473654
Molecular Function	GO:0005178	integrin binding	Tln1	IMP		Mouse	MGI:MGI:4439219|PMID:20150896
Molecular Function	GO:0005178	integrin binding	Tln1	IPI	RGD:2927	Rat	PMID:16935300|RGD:2325674
Molecular Function	GO:0030274	LIM domain binding	TLN1	IPI	UniProtKB:Q80XB4	Human	PMID:10320340
Molecular Function	GO:0035091	phosphatidylinositol binding	Tln1	IMP		Mouse	MGI:MGI:4439219|PMID:20150896
Molecular Function	GO:0001786	phosphatidylserine binding	Tln1	IMP		Mouse	MGI:MGI:4439219|PMID:20150896
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:P05556	Human	PMID:11279249
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:P05106	Human	PMID:16546176
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:O15061	Human	PMID:18342854
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:Q15327	Human	PMID:19608030
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:P18206	Human	PMID:26923917
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:Q9NS62	Human	PMID:27895300
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:Q2M1Z3	Human	PMID:32203420
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:O60331	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:P05106	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:P56180	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:Q2M1Z3	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TLN1	IPI	UniProtKB:Q6ZVC0	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:P05106|UniProtKB:P05556	Mouse	MGI:MGI:5915980|PMID:21134644
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:P12003	Mouse	MGI:MGI:3693386|PMID:15272303
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:P05106	Mouse	MGI:MGI:5914441|PMID:22210111
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:P12003	Mouse	MGI:MGI:4454350|PMID:20399778
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:P12003	Mouse	MGI:MGI:5926537|PMID:15642262
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:Q64727	Mouse	MGI:MGI:5508567|PMID:20308429
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:Q8R5A3	Mouse	MGI:MGI:5918754|PMID:27150043
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:P05556	Mouse	MGI:MGI:5306867|PMID:21947080
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:Q8R5A3	Mouse	MGI:MGI:5917515|PMID:25465129
Molecular Function	GO:0005515	protein binding	Tln1	IPI	UniProtKB:P05106	Mouse	MGI:MGI:3700398|PMID:17218263
Molecular Function	GO:0017166	vinculin binding	TLN1	IPI	UniProtKB:P18206	Human	PMID:15070891
Cellular Component	GO:0005912	adherens junction	TLN1	IMP		Human	PMID:26923917
Cellular Component	GO:0070062	extracellular exosome	TLN1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TLN1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	TLN1	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	TLN1	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	TLN1	IDA		Human	PMID:15070891
Cellular Component	GO:0005925	focal adhesion	TLN1	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	TLN1	IMP		Human	PMID:26923917
Cellular Component	GO:0005925	focal adhesion	Tln1	IDA		Mouse	PMID:11807098
Biological Process	GO:0055013	cardiac muscle cell development	tln1	IMP	ZFIN:ZDB-GENO-160317-2	Zfish	PMID:26310270
Biological Process	GO:0055013	cardiac muscle cell development	tln1	IMP	ZFIN:ZDB-MRPHLNO-160217-1	Zfish	PMID:26310270
Biological Process	GO:0055013	cardiac muscle cell development	tln1	IGI	ZFIN:ZDB-MRPHLNO-080319-2,ZFIN:ZDB-MRPHLNO-160217-1	Zfish	PMID:26310270
Biological Process	GO:0007044	cell-substrate junction assembly	Tln1	IMP		Mouse	PMID:12867986
Biological Process	GO:0061386	closure of optic fissure	tln1	IMP	ZFIN:ZDB-GENO-160317-1	Zfish	PMID:27634568
Biological Process	GO:0030866	cortical actin cytoskeleton organization	Tln1	IMP		Mouse	PMID:12867986
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	tln1	IMP	ZFIN:ZDB-GENO-160317-1	Zfish	PMID:29707441
Biological Process	GO:0033622	integrin activation	Tln1	IMP		Mouse	MGI:MGI:4439219|PMID:20150896
Biological Process	GO:0007229	integrin-mediated signaling pathway	Tln1	IMP		Mouse	MGI:MGI:4439219|PMID:20150896
Biological Process	GO:0014033	neural crest cell differentiation	tln1	IMP	ZFIN:ZDB-GENO-160317-1	Zfish	PMID:29707441
Biological Process	GO:0070527	platelet aggregation	TLN1	HMP		Human	PMID:23382103
Biological Process	GO:0045214	sarcomere organization	tln1	IMP	ZFIN:ZDB-MRPHLNO-160217-1	Zfish	PMID:26310270
Biological Process	GO:0045214	sarcomere organization	tln1	IMP	ZFIN:ZDB-GENO-160317-2	Zfish	PMID:26310270
Biological Process	GO:0007519	skeletal muscle tissue development	tln1	IMP	ZFIN:ZDB-GENO-181002-21	Zfish	PMID:29707441

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern