Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLE6
  • Mouse genes Tle6
  • Rat genes Tle6
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tle6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TLE6	IPI	UniProtKB:A6NGQ2,UniProtKB:Q587J8	Human	PMID:26537248
Molecular Function	GO:0005515	protein binding	TLE6	IPI	UniProtKB:P23560-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TLE6	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tle6	IPI	UniProtKB:P18760	Mouse	MGI:MGI:6296386|PMID:25208553
Molecular Function	GO:0005515	protein binding	Tle6	IPI	UniProtKB:Q9CWE6,UniProtKB:Q9R1M5	Mouse	MGI:MGI:6467696|PMID:28992324
Molecular Function	GO:0005515	protein binding	Tle6	IPI	UniProtKB:Q66X05|UniProtKB:Q66X05|UniProtKB:Q9CWE6|UniProtKB:Q9D0L1|UniProtKB:Q9R1M5	Mouse	MGI:MGI:6389592|PMID:31575650
Molecular Function	GO:0005515	protein binding	Tle6	IPI	UniProtKB:O88942|UniProtKB:P63015	Mouse	MGI:MGI:6478056|PMID:23990468
Molecular Function	GO:0005515	protein binding	Tle6	IPI	PR:Q60987	Mouse	PMID:16314515
Molecular Function	GO:0005515	protein binding	Tle6	IPI	PR:Q9R1M5	Mouse	PMID:18804437
Molecular Function	GO:0005515	protein binding	Tle6	IPI	PR:Q9CWE6	Mouse	PMID:18804437
Cellular Component	GO:0005938	cell cortex	Tle6	IDA		Mouse	MGI:MGI:6296386|PMID:25208553
Cellular Component	GO:0005938	cell cortex	Tle6	IDA		Mouse	PMID:18804437
Cellular Component	GO:0005938	cell cortex	Tle6	IDA		Mouse	PMID:19376971
Cellular Component	GO:0005634	nucleus	Tle6	IDA		Mouse	PMID:16314515
Cellular Component	GO:0032991	protein-containing complex	TLE6	IMP		Human	PMID:26537248
Cellular Component	GO:0032991	protein-containing complex	Tle6	IDA		Mouse	PMID:18191828
Cellular Component	GO:0106333	subcortical maternal complex	TLE6	IDA		Human	PMID:25542835
Cellular Component	GO:0106333	subcortical maternal complex	TLE6	IDA		Human	PMID:26537248
Cellular Component	GO:0106333	subcortical maternal complex	Tle6	IDA		Mouse	MGI:MGI:6389592|PMID:31575650
Cellular Component	GO:0106333	subcortical maternal complex	Tle6	IDA		Mouse	MGI:MGI:3811945|PMID:18804437
Cellular Component	GO:0106333	subcortical maternal complex	Tle6	IDA		Mouse	MGI:MGI:6467696|PMID:28992324
Biological Process	GO:0007015	actin filament organization	Tle6	IMP		Mouse	MGI:MGI:6389592|PMID:31575650
Biological Process	GO:0007015	actin filament organization	Tle6	IMP		Mouse	MGI:MGI:6296386|PMID:25208553
Biological Process	GO:0060136	embryonic process involved in female pregnancy	TLE6	IMP		Human	PMID:26537248
Biological Process	GO:0051643	endoplasmic reticulum localization	Tle6	IMP		Mouse	MGI:MGI:6467696|PMID:28992324
Biological Process	GO:0051293	establishment of spindle localization	Tle6	IMP		Mouse	MGI:MGI:6296386|PMID:25208553
Biological Process	GO:0051646	mitochondrion localization	Tle6	IMP		Mouse	MGI:MGI:6467696|PMID:28992324
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tle6	IDA		Mouse	MGI:MGI:6478056|PMID:23990468
Biological Process	GO:0040019	positive regulation of embryonic development	Tle6	IMP		Mouse	MGI:MGI:6296386|PMID:25208553
Biological Process	GO:0050769	positive regulation of neurogenesis	Tle6	IMP		Mouse	PMID:16314515
Biological Process	GO:0045666	positive regulation of neuron differentiation	Tle6	IGI	MGI:MGI:1347464	Mouse	PMID:16314515
Biological Process	GO:0051302	regulation of cell division	Tle6	IMP		Mouse	MGI:MGI:6296386|PMID:25208553
Biological Process	GO:0007284	spermatogonial cell division	Tle6	IMP		Mouse	MGI:MGI:6478070|PMID:32823735

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern