Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFR2
  • Mouse genes Tfr2
  • Rat genes Tfr2
  • Zfish genes tfr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0039706	co-receptor binding	TFR2	IPI	UniProtKB:Q6ZVN8	Human	PMID:22728873
Molecular Function	GO:0039706	co-receptor binding	TFR2	IPI	UniProtKB:Q96B86	Human	PMID:22728873
Molecular Function	GO:0005515	protein binding	TFR2	IPI	UniProtKB:P02787	Human	PMID:18353247
Molecular Function	GO:0005515	protein binding	TFR2	IPI	UniProtKB:Q30201	Human	PMID:18353247
Molecular Function	GO:0005515	protein binding	TFR2	IPI	UniProtKB:Q30201	Human	PMID:22728873
Molecular Function	GO:0005515	protein binding	TFR2	IPI	UniProtKB:P60033	Human	PMID:25635054
Molecular Function	GO:0005515	protein binding	TFR2	IPI	UniProtKB:P02787	Human	PMID:29388418
Molecular Function	GO:0005515	protein binding	TFR2	IPI	UniProtKB:Q6UX06	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFR2	IPI	UniProtKB:Q96IW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tfr2	IPI	UniProtKB:P70387	Mouse	MGI:MGI:3695785|PMID:16893896
Molecular Function	GO:0004998	transferrin receptor activity	TFR2	IDA		Human	PMID:18353247
Cellular Component	GO:0031410	cytoplasmic vesicle	TFR2	IDA		Human	PMID:12704209
Cellular Component	GO:0009897	external side of plasma membrane	TFR2	IGI	UniProtKB:P61769,UniProtKB:Q30201	Human	PMID:18353247
Cellular Component	GO:1990712	HFE-transferrin receptor complex	TFR2	IDA		Human	PMID:12704209
Cellular Component	GO:1990712	HFE-transferrin receptor complex	TFR2	IDA		Human	PMID:22728873
Cellular Component	GO:1990712	HFE-transferrin receptor complex	Tfr2	IDA		Mouse	MGI:MGI:3695785|PMID:16893896
Cellular Component	GO:0005886	plasma membrane	TFR2	IGI	UniProtKB:P61769,UniProtKB:Q30201	Human	PMID:18353247
Cellular Component	GO:0098794	postsynapse	Tfr2	IDA		Mouse	PMID:26880306
Biological Process	GO:0006953	acute-phase response	Tfr2	IEP		Rat	PMID:21437659|RGD:11062091
Biological Process	GO:0071281	cellular response to iron ion	TFR2	IGI	UniProtKB:P02787,UniProtKB:Q07891	Human	PMID:18353247
Biological Process	GO:0140298	endocytic iron import into cell	TFR2	IGI	UniProtKB:P02787	Human	PMID:18353247
Biological Process	GO:0140298	endocytic iron import into cell	TFR2	IGI	UniProtKB:P02787,UniProtKB:Q07891	Human	PMID:18353247
Biological Process	GO:0006879	intracellular iron ion homeostasis	TFR2	IDA		Human	PMID:18353247
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	TFR2	IMP		Human	PMID:21173098
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Tfr2	IMP	MGI:MGI:2384726	Mouse	PMID:22960056
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	tfr2	IMP	ZFIN:ZDB-GENO-181121-1	Zfish	PMID:29897731
Biological Process	GO:0045807	positive regulation of endocytosis	TFR2	IGI	UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q30201	Human	PMID:18353247
Biological Process	GO:0090277	positive regulation of peptide hormone secretion	TFR2	IMP		Human	PMID:21173098
Biological Process	GO:1903319	positive regulation of protein maturation	TFR2	IGI	UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q30201	Human	PMID:18353247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TFR2	IGI	UniProtKB:P60033	Human	PMID:25635054
Biological Process	GO:0006898	receptor-mediated endocytosis	TFR2	IGI	UniProtKB:Q07891,UniProtKB:Q30201	Human	PMID:18353247
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Tfr2	IDA		Mouse	PMID:26880306
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Tfr2	IEP		Mouse	PMID:26880306
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Tfr2	IMP		Mouse	PMID:26880306
Biological Process	GO:0010039	response to iron ion	TFR2	IMP		Human	PMID:21173098
Biological Process	GO:0033572	transferrin transport	TFR2	IGI	UniProtKB:P02787,UniProtKB:Q07891	Human	PMID:18353247

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern