Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPPL2C
  • Mouse genes Sppl2c
  • Rat genes Sppl2c
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sppl2c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Sppl2c	IDA		Mouse	MGI:MGI:6281843|PMID:30733280
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Sppl2c	IDA		Mouse	MGI:MGI:7387163|PMID:30733281
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Sppl2c	IDA		Mouse	MGI:MGI:7332329|PMID:35960805
Molecular Function	GO:0060090	molecular adaptor activity	Sppl2c	IDA		Mouse	MGI:MGI:7332329|PMID:35960805
Molecular Function	GO:0005515	protein binding	SPPL2C	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPPL2C	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Sppl2c	IPI	UniProtKB:Q8CF31	Mouse	MGI:MGI:7332329|PMID:35960805
Molecular Function	GO:0042803	protein homodimerization activity	SPPL2C	IDA		Human	PMID:15385547
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	SPPL2C	IDA		Human	PMID:15385547
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SPPL2C	IDA		Human	PMID:16829952
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Sppl2c	IDA		Mouse	MGI:MGI:6281843|PMID:30733280
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Sppl2c	IDA		Mouse	MGI:MGI:7332329|PMID:35960805
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Sppl2c	IDA		Mouse	MGI:MGI:7387163|PMID:30733281
Cellular Component	GO:0098553	lumenal side of endoplasmic reticulum membrane	SPPL2C	IDA		Human	PMID:15385547
Biological Process	GO:0001675	acrosome assembly	Sppl2c	IDA		Mouse	MGI:MGI:7387163|PMID:30733281
Biological Process	GO:0001675	acrosome assembly	Sppl2c	IDA		Mouse	MGI:MGI:6281843|PMID:30733280
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Sppl2c	IDA		Mouse	MGI:MGI:6281843|PMID:30733280
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	Sppl2c	IDA		Mouse	MGI:MGI:7387163|PMID:30733281

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern