Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPEF1
  • Mouse genes Spef1
  • Rat genes Spef1
  • Zfish genes spef1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spef1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	SPEF1	IDA		Human	PMID:31473225
Molecular Function	GO:0008017	microtubule binding	Spef1	IMP		Mouse	MGI:MGI:6331463|PMID:30535028
Molecular Function	GO:0008017	microtubule binding	Spef1	IDA		Mouse	MGI:MGI:5908342|PMID:16206169
Molecular Function	GO:0005515	protein binding	SPEF1	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPEF1	IPI	UniProtKB:P12830	Human	PMID:31473225
Molecular Function	GO:0005515	protein binding	SPEF1	IPI	UniProtKB:Q07157	Human	PMID:31473225
Molecular Function	GO:0005515	protein binding	SPEF1	IPI	UniProtKB:Q9P2M7	Human	PMID:31473225
Cellular Component	GO:0097729	9+2 motile cilium	Spef1	IDA		Mouse	MGI:MGI:6331463|PMID:30535028
Cellular Component	GO:0016324	apical plasma membrane	SPEF1	IDA		Human	PMID:31473225
Cellular Component	GO:1990716	axonemal central apparatus	Spef1	IDA		Mouse	MGI:MGI:6331463|PMID:30535028
Cellular Component	GO:0016323	basolateral plasma membrane	SPEF1	IDA		Human	PMID:31473225
Cellular Component	GO:0097542	ciliary tip	Spef1	IDA		Mouse	MGI:MGI:6331463|PMID:30535028
Cellular Component	GO:0005737	cytoplasm	SPEF1	IDA		Human	PMID:31473225
Cellular Component	GO:0005737	cytoplasm	Spef1	IDA		Mouse	PMID:15979255
Cellular Component	GO:0030175	filopodium	SPEF1	IDA		Human	PMID:31473225
Cellular Component	GO:0030027	lamellipodium	SPEF1	IDA		Human	PMID:31473225
Cellular Component	GO:0005874	microtubule	SPEF1	IDA		Human	PMID:31473225
Cellular Component	GO:0005902	microvillus	SPEF1	IDA		Human	PMID:31473225
Cellular Component	GO:0031514	motile cilium	Spef1	IDA		Mouse	PMID:15979255
Biological Process	GO:1904158	axonemal central apparatus assembly	Spef1	IMP		Mouse	MGI:MGI:6331463|PMID:30535028
Biological Process	GO:0003341	cilium movement	Spef1	IMP		Mouse	MGI:MGI:6331463|PMID:30535028
Biological Process	GO:0046847	filopodium assembly	SPEF1	IMP		Human	PMID:31473225
Biological Process	GO:0030032	lamellipodium assembly	SPEF1	IMP		Human	PMID:31473225
Biological Process	GO:0001578	microtubule bundle formation	Spef1	IDA		Mouse	MGI:MGI:6331463|PMID:30535028
Biological Process	GO:0060548	negative regulation of cell death	SPEF1	IMP		Human	PMID:31473225
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	Spef1	IDA		Mouse	MGI:MGI:5908342|PMID:16206169

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern