Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPECC1L
  • Mouse genes Specc1l
  • Rat genes Specc1l
  • Zfish genes specc1la,specc1lb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Specc1l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Specc1l	IPI	PR:Q02248	Mouse	PMID:26787558
Molecular Function	GO:0005515	protein binding	SPECC1L	IPI	UniProtKB:P15622-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPECC1L	IPI	UniProtKB:Q13573	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPECC1L	IPI	UniProtKB:Q14241	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPECC1L	IPI	UniProtKB:Q15911-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPECC1L	IPI	UniProtKB:Q8N7B9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPECC1L	IPI	UniProtKB:Q9BZL4	Human	PMID:32296183
Cellular Component	GO:0015629	actin cytoskeleton	SPECC1L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0015629	actin cytoskeleton	Specc1l	IDA		Mouse	PMID:21703590
Cellular Component	GO:0005911	cell-cell junction	Specc1l	IDA		Mouse	PMID:26787558
Cellular Component	GO:0005737	cytoplasm	Specc1l	IDA		Mouse	PMID:26787558
Cellular Component	GO:0031941	filamentous actin	Specc1l	IDA		Mouse	PMID:21703590
Cellular Component	GO:0015630	microtubule cytoskeleton	Specc1l	IDA		Mouse	PMID:21703590
Cellular Component	GO:0005815	microtubule organizing center	Specc1l	IDA		Mouse	PMID:21703590
Biological Process	GO:0030036	actin cytoskeleton organization	Specc1l	IMP		Mouse	PMID:21703590
Biological Process	GO:0030036	actin cytoskeleton organization	Specc1l	IMP	MGI:MGI:4124253	Mouse	PMID:26787558
Biological Process	GO:0030036	actin cytoskeleton organization	Specc1l	IMP		Mouse	PMID:26787558
Biological Process	GO:0034332	adherens junction organization	Specc1l	IMP		Mouse	PMID:26787558
Biological Process	GO:0034332	adherens junction organization	Specc1l	IMP	MGI:MGI:4124253	Mouse	PMID:26787558
Biological Process	GO:0061713	anterior neural tube closure	Specc1l	IMP	MGI:MGI:4128888	Mouse	PMID:26787558
Biological Process	GO:0061713	anterior neural tube closure	Specc1l	IMP	MGI:MGI:4124253	Mouse	PMID:26787558
Biological Process	GO:0061713	anterior neural tube closure	Specc1l	IMP	MGI:MGI:4124253,MGI:MGI:4128888	Mouse	PMID:26787558
Biological Process	GO:0007155	cell adhesion	SPECC1L	IDA		Human	PMID:21703590
Biological Process	GO:0016477	cell migration	Specc1l	IMP		Mouse	PMID:21703590
Biological Process	GO:1904888	cranial skeletal system development	specc1lb	IMP	ZFIN:ZDB-MRPHLNO-140313-1	Zfish	PMID:25357034
Biological Process	GO:0060325	face morphogenesis	specc1la	IDA		Zfish	PMID:21703590|ZFIN:ZDB-PUB-110629-38
Biological Process	GO:0097095	frontonasal suture morphogenesis	specc1lb	IMP	ZFIN:ZDB-MRPHLNO-140313-1	Zfish	PMID:24121214
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	Specc1l	IDA		Mouse	PMID:21703590
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	Specc1l	IDA		Mouse	PMID:21703590
Biological Process	GO:0036032	neural crest cell delamination	Specc1l	IMP	MGI:MGI:4124253,MGI:MGI:4128888	Mouse	PMID:26787558
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Specc1l	IMP		Mouse	PMID:26787558
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Specc1l	IMP	MGI:MGI:4124253	Mouse	PMID:26787558

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern