Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPAG6
  • Mouse genes Spag6l
  • Rat genes Spag6l
  • Zfish genes spag6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spag6l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008017	microtubule binding	Spag6l	IDA		Mouse	PMID:12391165
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	UniProtKB:Q5S003	Mouse	MGI:MGI:3807761|PMID:15827353
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:O35864	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:P26041	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:Q9Z266	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:Q8BMY7	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:Q8K450	Mouse	PMID:12391165
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:P41539	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:P11985	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:Q99NH7	Mouse	PMID:25748314
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:P61161	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:Q9JM76	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:Q64368	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Spag6l	IPI	PR:Q8C1Z7	Mouse	PMID:31146259
Cellular Component	GO:0001669	acrosomal vesicle	Spag6l	IDA		Mouse	PMID:31146259
Cellular Component	GO:1990716	axonemal central apparatus	Spag6l	IGI	MGI:MGI:1913972	Mouse	PMID:17699735
Cellular Component	GO:0005930	axoneme	SPAG6	IDA		Human	PMID:10493827
Cellular Component	GO:0005930	axoneme	Spag6l	IDA		Mouse	MGI:MGI:6331463|PMID:30535028
Cellular Component	GO:0031410	cytoplasmic vesicle	Spag6l	IDA		Mouse	PMID:31146259
Cellular Component	GO:0005829	cytosol	Spag6l	IDA		Mouse	PMID:28819108
Cellular Component	GO:0120249	lateral wall of outer hair cell	Spag6l	IDA		Mouse	PMID:25748314
Cellular Component	GO:0002177	manchette	Spag6l	IDA		Mouse	PMID:31146259
Cellular Component	GO:0015630	microtubule cytoskeleton	SPAG6	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	SPAG6	HDA		Human	PMID:21630459
Cellular Component	GO:0097228	sperm principal piece	SPAG6	IDA		Human	PMID:30137358
Cellular Component	GO:0097228	sperm principal piece	Spag6l	IDA		Mouse	PMID:10684790
Biological Process	GO:0051301	cell division	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:26585507
Biological Process	GO:0090660	cerebrospinal fluid circulation	Spag6l	IGI	MGI:MGI:1913972	Mouse	PMID:17323374
Biological Process	GO:0090660	cerebrospinal fluid circulation	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25393619
Biological Process	GO:0043583	ear development	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25748314
Biological Process	GO:0003351	epithelial cilium movement involved in extracellular fluid movement	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25393619
Biological Process	GO:0003351	epithelial cilium movement involved in extracellular fluid movement	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:12167721
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25333478
Biological Process	GO:0051649	establishment of localization in cell	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25393619
Biological Process	GO:0010761	fibroblast migration	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:26585507
Biological Process	GO:0046847	filopodium assembly	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:26585507
Biological Process	GO:0030317	flagellated sperm motility	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:12167721
Biological Process	GO:0044458	motile cilium assembly	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25333478
Biological Process	GO:0044458	motile cilium assembly	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25393619
Biological Process	GO:0120197	mucociliary clearance	Spag6l	IGI	MGI:MGI:1913972	Mouse	PMID:17323374
Biological Process	GO:1990138	neuron projection extension	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:28819108
Biological Process	GO:1905515	non-motile cilium assembly	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:26585507
Biological Process	GO:0008104	protein localization	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:31146259
Biological Process	GO:0008104	protein localization	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25748314
Biological Process	GO:0003356	regulation of cilium beat frequency	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25333478
Biological Process	GO:0090175	regulation of establishment of planar polarity	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:25393619
Biological Process	GO:0007288	sperm axoneme assembly	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:12391165
Biological Process	GO:0007283	spermatogenesis	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:31146259
Biological Process	GO:0043149	stress fiber assembly	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:26585507
Biological Process	GO:0006931	substrate-dependent cell migration, cell attachment to substrate	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:26585507
Biological Process	GO:0021591	ventricular system development	Spag6l	IMP	MGI:MGI:2662475	Mouse	PMID:12167721

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern