Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMYD2
  • Mouse genes Smyd2
  • Rat genes Smyd2
  • Zfish genes smyd2a,smyd2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smyd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	Smyd2	IDA		Mouse	MGI:MGI:4943402|PMID:16805913
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	Smyd2	IDA		Mouse	PMID:22862948
Molecular Function	GO:0002039	p53 binding	SMYD2	IPI	UniProtKB:P04637	Human	PMID:17108971
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:P04637	Human	PMID:17805299
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:P06400	Human	PMID:20870719
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:P04637	Human	PMID:21782458
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:P08238	Human	PMID:24880080
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:P04637	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:Q9UPZ9	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:P20290-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:Q96K17	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:Q9Y5W9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD2	IPI	UniProtKB:Q9UPZ9	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Smyd2	IPI	UniProtKB:Q6DFV5	Mouse	MGI:MGI:4440782|PMID:20305823
Molecular Function	GO:0005515	protein binding	Smyd2	IPI	UniProtKB:P04637	Mouse	MGI:MGI:5916913|PMID:17108971
Molecular Function	GO:0005515	protein binding	Smyd2	IPI	UniProtKB:O09106|UniProtKB:Q60520	Mouse	MGI:MGI:4943402|PMID:16805913
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	SMYD2	IDA		Human	PMID:17108971
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	SMYD2	IDA		Human	PMID:20870719
Molecular Function	GO:0000993	RNA polymerase II complex binding	Smyd2	IDA		Mouse	MGI:MGI:4440782|PMID:20305823
Cellular Component	GO:0005737	cytoplasm	SMYD2	IDA		Human	PMID:24880080
Cellular Component	GO:0005737	cytoplasm	Smyd2	IDA		Mouse	MGI:MGI:4943402|PMID:16805913
Cellular Component	GO:0005737	cytoplasm	Smyd2	IDA		Rat	PMID:23047121|RGD:9586366
Cellular Component	GO:0005829	cytosol	Smyd2	IDA		Mouse	MGI:MGI:4440782|PMID:20305823
Cellular Component	GO:0005829	cytosol	Smyd2	IDA		Rat	PMID:20305823|RGD:9586367
Cellular Component	GO:0005634	nucleus	Smyd2	IDA		Mouse	MGI:MGI:4440782|PMID:20305823
Cellular Component	GO:0005634	nucleus	Smyd2	IDA		Mouse	MGI:MGI:4943402|PMID:16805913
Cellular Component	GO:0005634	nucleus	Smyd2	IDA		Rat	PMID:20305823|RGD:9586367
Biological Process	GO:0033336	caudal fin development	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-150807-3	Zfish	PMID:23873367
Biological Process	GO:0060047	heart contraction	smyd2b	IGI	ZFIN:ZDB-MRPHLNO-120824-2,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0060047	heart contraction	smyd2b	IGI	ZFIN:ZDB-MRPHLNO-120824-1,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0060047	heart contraction	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-2	Zfish	PMID:23047121
Biological Process	GO:0060047	heart contraction	smyd2a	IGI	ZFIN:ZDB-MRPHLNO-120824-1,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0060047	heart contraction	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-1	Zfish	PMID:23047121
Biological Process	GO:0060047	heart contraction	smyd2a	IGI	ZFIN:ZDB-MRPHLNO-120824-2,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0007507	heart development	Smyd2	IEP		Rat	PMID:20305823|RGD:9586367
Biological Process	GO:0007507	heart development	smyd2b	IGI	ZFIN:ZDB-MRPHLNO-120824-1,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0007507	heart development	smyd2b	IGI	ZFIN:ZDB-MRPHLNO-120824-2,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0007507	heart development	smyd2b	IGI	ZFIN:ZDB-MRPHLNO-120824-2,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:22241783
Biological Process	GO:0007507	heart development	smyd2b	IGI	ZFIN:ZDB-MRPHLNO-120824-1,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:22241783
Biological Process	GO:0007507	heart development	smyd2a	IGI	ZFIN:ZDB-MRPHLNO-120824-2,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:22241783
Biological Process	GO:0007507	heart development	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-1	Zfish	PMID:23047121
Biological Process	GO:0007507	heart development	smyd2a	IGI	ZFIN:ZDB-MRPHLNO-120824-2,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0007507	heart development	smyd2a	IGI	ZFIN:ZDB-MRPHLNO-120824-1,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:22241783
Biological Process	GO:0007507	heart development	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-2	Zfish	PMID:23047121
Biological Process	GO:0007507	heart development	smyd2a	IGI	ZFIN:ZDB-MRPHLNO-120824-1,ZFIN:ZDB-MRPHLNO-120824-3	Zfish	PMID:23047121
Biological Process	GO:0016570	histone modification	Smyd2	IDA		Mouse	MGI:MGI:5447149|PMID:22862948
Biological Process	GO:0008285	negative regulation of cell population proliferation	Smyd2	IDA		Mouse	MGI:MGI:4943402|PMID:16805913
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SMYD2	IMP		Human	PMID:17108971
Biological Process	GO:0018027	peptidyl-lysine dimethylation	Smyd2	IDA		Mouse	MGI:MGI:4943402|PMID:16805913
Biological Process	GO:0018026	peptidyl-lysine monomethylation	SMYD2	IDA		Human	PMID:17108971
Biological Process	GO:0018026	peptidyl-lysine monomethylation	SMYD2	IDA		Human	PMID:20870719
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	SMYD2	IMP		Human	PMID:17108971
Biological Process	GO:0060297	regulation of sarcomere organization	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-1	Zfish	PMID:22241783
Biological Process	GO:0060297	regulation of sarcomere organization	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-2	Zfish	PMID:22241783
Biological Process	GO:0007519	skeletal muscle tissue development	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-1	Zfish	PMID:22241783
Biological Process	GO:0007519	skeletal muscle tissue development	smyd2a	IMP	ZFIN:ZDB-MRPHLNO-120824-2	Zfish	PMID:22241783

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern