Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMPDL3B
  • Mouse genes Smpdl3b
  • Rat genes Smpdl3b
  • Zfish genes smpdl3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smpdl3b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	SMPDL3B	IMP		Human	PMID:26095358
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	Smpdl3b	IMP		Mouse	MGI:MGI:5689225|PMID:26095358
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	Smpdl3b	IDA		Mouse	MGI:MGI:6282973|PMID:27687724
Molecular Function	GO:0005515	protein binding	Smpdl3b	IPI	UniProtKB:P58681|UniProtKB:P58682|UniProtKB:Q9EQU3|UniProtKB:Q9QUK6	Mouse	MGI:MGI:5689225|PMID:26095358
Molecular Function	GO:0008270	zinc ion binding	Smpdl3b	IDA		Mouse	MGI:MGI:6282973|PMID:27687724
Cellular Component	GO:0070062	extracellular exosome	SMPDL3B	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SMPDL3B	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	SMPDL3B	HDA		Human	PMID:16502470
Cellular Component	GO:0005886	plasma membrane	Smpdl3b	IDA		Mouse	MGI:MGI:5689225|PMID:26095358
Biological Process	GO:0046466	membrane lipid catabolic process	Smpdl3b	IMP		Mouse	MGI:MGI:5689225|PMID:26095358
Biological Process	GO:0050728	negative regulation of inflammatory response	Smpdl3b	IMP		Mouse	MGI:MGI:5689225|PMID:26095358
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	Smpdl3b	IMP		Mouse	MGI:MGI:5689225|PMID:26095358

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern