Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMPD5
  • Mouse genes Smpd5
  • Rat genes Smpd5
  • Zfish genes smpd5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smpd5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd5	IDA		Mouse	MGI:MGI:6450238|PMID:21183079
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd5	IDA		Mouse	PMID:20378533
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	smpd5	IDA		Zfish	PMID:19429680
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Smpd5	IDA		Mouse	MGI:MGI:6450238|PMID:21183079
Cellular Component	GO:0005758	mitochondrial intermembrane space	smpd5	IDA		Zfish	PMID:19429680
Cellular Component	GO:0031966	mitochondrial membrane	Smpd5	IDA		Mouse	MGI:MGI:6450238|PMID:21183079
Cellular Component	GO:0005739	mitochondrion	Smpd5	IDA		Mouse	PMID:20378533
Biological Process	GO:0046513	ceramide biosynthetic process	Smpd5	IDA		Mouse	MGI:MGI:6450238|PMID:21183079
Biological Process	GO:0006672	ceramide metabolic process	Smpd5	IDA		Mouse	PMID:20378533
Biological Process	GO:0006687	glycosphingolipid metabolic process	smpd5	IDA		Zfish	PMID:19429680
Biological Process	GO:0006685	sphingomyelin catabolic process	Smpd5	IDA		Mouse	MGI:MGI:6450238|PMID:21183079

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern