Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMC4
  • Mouse genes Smc4
  • Rat genes Smc4
  • Zfish genes smc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Smc4	IDA		Mouse	PMID:23531880
Molecular Function	GO:0005515	protein binding	SMC4	IPI	UniProtKB:O95347	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC4	IPI	UniProtKB:O95347	Human	PMID:17268547
Molecular Function	GO:0005515	protein binding	SMC4	IPI	UniProtKB:Q15003	Human	PMID:17268547
Molecular Function	GO:0005515	protein binding	SMC4	IPI	UniProtKB:Q6IBW4	Human	PMID:17268547
Molecular Function	GO:0005515	protein binding	SMC4	IPI	UniProtKB:Q15003	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC4	IPI	UniProtKB:O95347	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	SMC4	IPI	UniProtKB:O95347	Human	PMID:9789013
Molecular Function	GO:0005515	protein binding	Smc4	IPI	UniProtKB:Q00899	Mouse	MGI:MGI:5484711|PMID:23531880
Molecular Function	GO:0005515	protein binding	Smc4	IPI	UniProtKB:Q8CG48	Mouse	PMID:20139420
Molecular Function	GO:0003697	single-stranded DNA binding	Smc4	IDA		Mouse	PMID:20139420
Cellular Component	GO:0000775	chromosome, centromeric region	Smc4	IDA		Mouse	PMID:26919979
Cellular Component	GO:0000794	condensed nuclear chromosome	Smc4	IDA		Mouse	MGI:MGI:5644098|PMID:25474630
Cellular Component	GO:0000796	condensin complex	SMC4	IDA		Human	PMID:11136719
Cellular Component	GO:0000796	condensin complex	SMC4	IDA		Human	PMID:9789013
Cellular Component	GO:0000796	condensin complex	Smc4	IDA		Mouse	PMID:21795393
Cellular Component	GO:0005829	cytosol	SMC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	SMC4	IDA		Human	GO_REF:0000052
Biological Process	GO:0051383	kinetochore organization	Smc4	IMP		Mouse	PMID:21795393
Biological Process	GO:0010032	meiotic chromosome condensation	Smc4	IMP		Mouse	PMID:21795393
Biological Process	GO:0045132	meiotic chromosome segregation	Smc4	IMP		Mouse	PMID:21795393
Biological Process	GO:0007076	mitotic chromosome condensation	SMC4	IDA		Human	PMID:11136719
Biological Process	GO:1905821	positive regulation of chromosome condensation	SMC4	IDA		Human	PMID:17268547
Biological Process	GO:0051984	positive regulation of chromosome segregation	Smc4	IMP		Mouse	MGI:MGI:5644098|PMID:25474630
Biological Process	GO:1905820	positive regulation of chromosome separation	Smc4	IMP		Mouse	MGI:MGI:5317363|PMID:21795393

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern