Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMC3
  • Mouse genes Smc3
  • Rat genes Smc3
  • Zfish genes smc3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048487	beta-tubulin binding	SMC3	IDA		Human	PMID:11590136
Molecular Function	GO:0003682	chromatin binding	Smc3	IDA		Mouse	PMID:20720539
Molecular Function	GO:0003682	chromatin binding	Smc3	IDA		Mouse	PMID:22415368
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	smc3	IPI	ZFIN:ZDB-GENE-991105-4	Zfish	PMID:29084713
Molecular Function	GO:0070840	dynein complex binding	SMC3	IDA		Human	PMID:11590136
Molecular Function	GO:0036033	mediator complex binding	Smc3	IDA		Mouse	PMID:20720539
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14980	Human	PMID:11590136
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:P32908	Human	PMID:11983169
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q86T90	Human	PMID:15656913
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:15737063
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9CPY3	Human	PMID:15837422
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:15855230
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q29RF7	Human	PMID:15855230
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:15855230
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:15855230
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9NTI5	Human	PMID:15855230
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:16682347
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:16682347
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9BVC3	Human	PMID:16682347
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:16802858
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q96FC9	Human	PMID:17105772
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q29RF7	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9NTI5	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:17349791
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:17349791
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q29RF7	Human	PMID:17349791
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:17349791
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:17349791
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9NTI5	Human	PMID:17349791
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:17962804
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:17962804
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:18235444
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:18235444
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:18832153
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:19629043
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q29RF7	Human	PMID:19907496
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q7Z5K2	Human	PMID:19907496
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:20818333
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9NTI5	Human	PMID:22293751
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9BTE3	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:22628566
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:22885700
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:22885700
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:22885700
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:22885700
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:23242214
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q9BTE3	Human	PMID:24299456
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:O60216	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:29263825
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8N3U4	Human	PMID:29867216
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q8WVM7	Human	PMID:29867216
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q92845	Human	PMID:9506951
Molecular Function	GO:0005515	protein binding	SMC3	IPI	UniProtKB:Q14683	Human	PMID:9789013
Molecular Function	GO:0005515	protein binding	Smc3	IPI	UniProtKB:Q61550,UniProtKB:Q9CU62	Mouse	MGI:MGI:1340883|PMID:10375619
Molecular Function	GO:0005515	protein binding	Smc3	IPI	UniProtKB:Q9Z2D6	Mouse	MGI:MGI:4439201|PMID:20159591
Molecular Function	GO:0005515	protein binding	Smc3	IPI	PR:P70281	Mouse	PMID:12759374
Molecular Function	GO:0005515	protein binding	Smc3	IPI	PR:Q920F6	Mouse	PMID:12759374
Molecular Function	GO:0005515	protein binding	Smc3	IPI	PR:Q8C5S7	Mouse	PMID:12759374
Molecular Function	GO:0046982	protein heterodimerization activity	SMC3	IPI	UniProtKB:Q14683	Human	PMID:11590136
Cellular Component	GO:0005604	basement membrane	Smc3	IDA		Rat	PMID:9015313|RGD:61563
Cellular Component	GO:0000785	chromatin	SMC3	IDA		Human	PMID:16682347
Cellular Component	GO:0000785	chromatin	SMC3	IDA		Human	PMID:19907496
Cellular Component	GO:0008278	cohesin complex	SMC3	IDA		Human	PMID:11590136
Cellular Component	GO:0008278	cohesin complex	SMC3	IDA		Human	PMID:22628566
Cellular Component	GO:0008278	cohesin complex	SMC3	IDA		Human	PMID:9789013
Cellular Component	GO:0008278	cohesin complex	Smc3	IDA		Mouse	MGI:MGI:1340883|PMID:10375619
Cellular Component	GO:0000800	lateral element	Smc3	IDA		Mouse	PMID:15870106
Cellular Component	GO:0000800	lateral element	Smc3	IDA		Mouse	PMID:22711701
Cellular Component	GO:0000800	lateral element	Smc3	IDA		Mouse	PMID:32328639
Cellular Component	GO:0030893	meiotic cohesin complex	SMC3	IDA		Human	PMID:21242291
Cellular Component	GO:0030893	meiotic cohesin complex	Smc3	IDA		Mouse	MGI:MGI:5050018|PMID:21527826
Cellular Component	GO:0030893	meiotic cohesin complex	Smc3	IDA		Mouse	PMID:21743440
Cellular Component	GO:0030893	meiotic cohesin complex	Smc3	IDA		Mouse	PMID:22164254
Cellular Component	GO:0097431	mitotic spindle pole	SMC3	IDA		Human	PMID:11590136
Cellular Component	GO:0016363	nuclear matrix	SMC3	IDA		Human	PMID:11590136
Cellular Component	GO:0005654	nucleoplasm	SMC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Smc3	IDA		Mouse	MGI:MGI:1340883|PMID:10375619
Cellular Component	GO:0005634	nucleus	Smc3	IDA		Mouse	PMID:12759374
Cellular Component	GO:0005634	nucleus	Smc3	IDA		Rat	PMID:10652260|RGD:1331378
Cellular Component	GO:0000795	synaptonemal complex	Smc3	IDA		Rat	PMID:10652260|RGD:1331378
Biological Process	GO:0031101	fin regeneration	smc3	IMP	ZFIN:ZDB-MRPHLNO-070819-2	Zfish	PMID:29084713
Biological Process	GO:0031101	fin regeneration	smc3	IGI	ZFIN:ZDB-GENE-991105-4	Zfish	PMID:29084713
Biological Process	GO:0031101	fin regeneration	smc3	IGI	ZFIN:ZDB-GENE-030131-3196	Zfish	PMID:29084713
Biological Process	GO:0051321	meiotic cell cycle	SMC3	IDA		Human	PMID:12498344
Biological Process	GO:0051321	meiotic cell cycle	Smc3	IPI	PR:P70281	Mouse	PMID:12759374
Biological Process	GO:0051321	meiotic cell cycle	Smc3	IEP		Rat	PMID:10652260|RGD:1331378
Biological Process	GO:0007064	mitotic sister chromatid cohesion	smc3	IMP	ZFIN:ZDB-MRPHLNO-070819-2	Zfish	PMID:17567667
Biological Process	GO:0007064	mitotic sister chromatid cohesion	smc3	IMP	ZFIN:ZDB-MRPHLNO-070819-1	Zfish	PMID:17567667
Biological Process	GO:0007064	mitotic sister chromatid cohesion	smc3	IMP	ZFIN:ZDB-MRPHLNO-070904-6	Zfish	PMID:17567667
Biological Process	GO:0007064	mitotic sister chromatid cohesion	smc3	IMP	ZFIN:ZDB-MRPHLNO-070904-7	Zfish	PMID:17567667
Biological Process	GO:0090307	mitotic spindle assembly	SMC3	IMP		Human	PMID:11590136
Biological Process	GO:0006275	regulation of DNA replication	SMC3	IMP		Human	PMID:19907496
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	smc3	IMP	ZFIN:ZDB-MRPHLNO-070819-2	Zfish	PMID:29084713
Biological Process	GO:0007062	sister chromatid cohesion	SMC3	IMP		Human	PMID:15917200
Biological Process	GO:0019827	stem cell population maintenance	Smc3	IMP		Mouse	PMID:20720539

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern