Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMAD6
  • Mouse genes Smad6
  • Rat genes Smad6
  • Zfish genes smad6a,smad6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smad6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	SMAD6	IDA		Human	PMID:16491121
Molecular Function	GO:0070410	co-SMAD binding	SMAD6	IPI	UniProtKB:Q13485	Human	PMID:9256479
Molecular Function	GO:0070411	I-SMAD binding	SMAD6	IPI	UniProtKB:O15105	Human	PMID:9256479
Molecular Function	GO:0042802	identical protein binding	SMAD6	IPI	UniProtKB:O43541	Human	PMID:9436979
Molecular Function	GO:0005515	protein binding	SMAD6	IPI	UniProtKB:Q13950	Human	PMID:16299379
Molecular Function	GO:0005515	protein binding	SMAD6	IPI	UniProtKB:P51817	Human	PMID:16491121
Molecular Function	GO:0005515	protein binding	SMAD6	IPI	UniProtKB:Q15797	Human	PMID:9436979
Molecular Function	GO:0005515	protein binding	Smad6	IPI	UniProtKB:P36898|UniProtKB:Q9JIF0	Mouse	MGI:MGI:5512842|PMID:17118358
Molecular Function	GO:0005515	protein binding	Smad6	IPI	UniProtKB:P36898|UniProtKB:Q9C0C9	Mouse	MGI:MGI:5508676|PMID:23455153
Molecular Function	GO:0005515	protein binding	Smad6	IPI	PR:O35625	Mouse	PMID:16601693
Molecular Function	GO:0070412	R-SMAD binding	SMAD6	IPI	UniProtKB:Q15796	Human	PMID:9256479
Molecular Function	GO:0070412	R-SMAD binding	SMAD6	IPI	UniProtKB:Q15797	Human	PMID:9436979
Molecular Function	GO:0000976	transcription cis-regulatory region binding	SMAD6	IDA		Human	PMID:16491121
Molecular Function	GO:0140416	transcription regulator inhibitor activity	SMAD6	IDA		Human	PMID:9256479
Molecular Function	GO:0070698	type I activin receptor binding	SMAD6	IDA		Human	PMID:9436979
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	SMAD6	IDA		Human	PMID:9436979
Molecular Function	GO:0031625	ubiquitin protein ligase binding	SMAD6	IPI	UniProtKB:Q9HCE7	Human	PMID:11278251
Cellular Component	GO:0005829	cytosol	SMAD6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	SMAD6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	SMAD6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SMAD6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SMAD6	IDA		Human	PMID:16491121
Cellular Component	GO:0032991	protein-containing complex	SMAD6	IDA		Human	PMID:23610558
Biological Process	GO:0035904	aorta development	Smad6	IMP		Mouse	PMID:25807483
Biological Process	GO:0003180	aortic valve morphogenesis	SMAD6	IMP		Human	PMID:22275001
Biological Process	GO:0030509	BMP signaling pathway	SMAD6	IDA		Human	PMID:23455153
Biological Process	GO:0031589	cell-substrate adhesion	SMAD6	IMP		Human	PMID:16491121
Biological Process	GO:0060976	coronary vasculature development	Smad6	IMP		Mouse	PMID:25807483
Biological Process	GO:0045444	fat cell differentiation	SMAD6	IDA		Human	PMID:23455153
Biological Process	GO:0007507	heart development	smad6a	IMP		Zfish	PMID:22247485
Biological Process	GO:0003170	heart valve development	Smad6	IMP		Mouse	PMID:25807483
Biological Process	GO:0006955	immune response	SMAD6	IMP		Human	PMID:16886151
Biological Process	GO:0003183	mitral valve morphogenesis	Smad6	IMP		Mouse	MGI:MGI:1352979|PMID:10655064
Biological Process	GO:0043066	negative regulation of apoptotic process	SMAD6	IMP		Human	PMID:19047146
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SMAD6	IMP		Human	PMID:22275001
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SMAD6	IMP		Human	PMID:30848080
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SMAD6	IDA		Human	PMID:9436979
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	smad6a	IMP		Zfish	PMID:22247485
Biological Process	GO:0008285	negative regulation of cell population proliferation	SMAD6	IMP		Human	PMID:19047146
Biological Process	GO:0030279	negative regulation of ossification	Smad6	IMP		Mouse	MGI:MGI:1352979|PMID:10655064
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	SMAD6	IMP		Human	PMID:22275001
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	SMAD6	IMP		Human	PMID:19047146
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	SMAD6	IDA		Human	PMID:9436979
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	smad6a	IMP		Zfish	PMID:22247485
Biological Process	GO:0010991	negative regulation of SMAD protein complex assembly	SMAD6	IDA		Human	PMID:9436979
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMAD6	IMP		Human	PMID:19047146
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMAD6	IDA		Human	PMID:9256479
Biological Process	GO:0003148	outflow tract septum morphogenesis	Smad6	IMP		Mouse	MGI:MGI:1352979|PMID:10655064
Biological Process	GO:1902895	positive regulation of miRNA transcription	Smad6	IMP		Mouse	MGI:MGI:4939577|PMID:21145505
Biological Process	GO:0003184	pulmonary valve morphogenesis	Smad6	IMP		Mouse	MGI:MGI:1352979|PMID:10655064
Biological Process	GO:0043627	response to estrogen	Smad6	IEP		Rat	PMID:10363999|RGD:2315072
Biological Process	GO:0034616	response to laminar fluid shear stress	SMAD6	IEP		Human	PMID:9256479
Biological Process	GO:0032496	response to lipopolysaccharide	SMAD6	IDA		Human	PMID:19193853
Biological Process	GO:0001657	ureteric bud development	Smad6	IEP		Mouse	MGI:MGI:3525982|PMID:14656760
Biological Process	GO:0003281	ventricular septum development	Smad6	IMP		Mouse	PMID:25807483
Biological Process	GO:0007352	zygotic specification of dorsal/ventral axis	SMAD6	IMP		Human	PMID:9436979

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern