Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLFN11,SLFN13
  • Mouse genes Slfn8
  • Rat genes Slfn13
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slfn8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016887	ATP hydrolysis activity	SLFN11	IDA		Human	PMID:29395061
Molecular Function	GO:0005515	protein binding	SLFN11	IPI	UniProtKB:P25205	Human	PMID:29395061
Molecular Function	GO:0005515	protein binding	SLFN11	IPI	UniProtKB:P27694	Human	PMID:29395061
Molecular Function	GO:0005515	protein binding	SLFN11	IPI	UniProtKB:Q08211	Human	PMID:29395061
Molecular Function	GO:0004521	RNA endonuclease activity	SLFN13	IDA		Human	PMID:29563550
Molecular Function	GO:0004521	RNA endonuclease activity	Slfn8	IDA		Mouse	MGI:MGI:6149438|PMID:29563550
Molecular Function	GO:0004521	RNA endonuclease activity	Slfn13	IDA		Rat	PMID:29563550|RGD:13601999
Molecular Function	GO:0000049	tRNA binding	SLFN11	IDA		Human	PMID:23000900
Molecular Function	GO:0008270	zinc ion binding	Slfn13	IDA		Rat	PMID:29563550|RGD:13601999
Cellular Component	GO:0005737	cytoplasm	SLFN13	IDA		Human	PMID:29563550
Cellular Component	GO:0005829	cytosol	SLFN11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SLFN11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SLFN11	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	SLFN11	IDA		Human	PMID:22927417
Cellular Component	GO:0005634	nucleus	SLFN11	IDA		Human	PMID:29395061
Cellular Component	GO:0090734	site of DNA damage	SLFN11	IDA		Human	PMID:29395061
Biological Process	GO:0051607	defense response to virus	SLFN11	IMP		Human	PMID:23000900
Biological Process	GO:0006974	DNA damage response	SLFN11	IDA		Human	PMID:29395061
Biological Process	GO:0008156	negative regulation of DNA replication	SLFN11	IDA		Human	PMID:29395061
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	SLFN11	IMP		Human	PMID:22927417
Biological Process	GO:0010942	positive regulation of cell death	SLFN11	IDA		Human	PMID:29395061
Biological Process	GO:0043111	replication fork arrest	SLFN11	IDA		Human	PMID:29395061
Biological Process	GO:0016075	rRNA catabolic process	SLFN13	IDA		Human	PMID:29563550
Biological Process	GO:0016075	rRNA catabolic process	Slfn8	IDA		Mouse	MGI:MGI:6149438|PMID:29563550
Biological Process	GO:0016075	rRNA catabolic process	Slfn13	IDA		Rat	PMID:29563550|RGD:13601999
Biological Process	GO:0016078	tRNA catabolic process	SLFN13	IDA		Human	PMID:29563550
Biological Process	GO:0016078	tRNA catabolic process	Slfn8	IDA		Mouse	MGI:MGI:6149438|PMID:29563550
Biological Process	GO:0016078	tRNA catabolic process	Slfn13	IDA		Rat	PMID:29563550|RGD:13601999

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern