Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLFN12,SLFN12L
  • Mouse genes Slfn1
  • Rat genes
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slfn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140102	catalytic activity, acting on a rRNA	SLFN12	IMP		Human	PMID:35104454
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:Q14432	Human	PMID:31420216
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:O15269-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P01019	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P02545	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P03952	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P06307	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P06858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P54577	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:Q86WV8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:Q9BY11	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:Q14432	Human	PMID:34272366
Molecular Function	GO:0005515	protein binding	SLFN12	IPI	UniProtKB:Q14432	Human	PMID:35104454
Molecular Function	GO:0005515	protein binding	Slfn1	IPI	PR:O54946	Mouse	PMID:18373498
Molecular Function	GO:0043022	ribosome binding	SLFN12	IDA		Human	PMID:31420216
Molecular Function	GO:0004540	RNA nuclease activity	SLFN12	IDA		Human	PMID:34272366
Molecular Function	GO:0004540	RNA nuclease activity	SLFN12	IMP		Human	PMID:35104454
Cellular Component	GO:0005737	cytoplasm	Slfn1	IDA		Mouse	PMID:18373498
Cellular Component	GO:0005829	cytosol	SLFN12	IDA		Human	PMID:35104454
Cellular Component	GO:0005634	nucleus	SLFN12	IDA		Human	PMID:35104454
Cellular Component	GO:0005634	nucleus	Slfn1	IDA		Mouse	PMID:18373498
Biological Process	GO:0097190	apoptotic signaling pathway	SLFN12	IMP		Human	PMID:31420216
Biological Process	GO:0097190	apoptotic signaling pathway	SLFN12	IMP		Human	PMID:35104454
Biological Process	GO:0008285	negative regulation of cell population proliferation	Slfn1	IDA		Mouse	PMID:9846487
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Slfn1	IGI	MGI:MGI:88313	Mouse	PMID:15946944
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Slfn1	IDA		Mouse	PMID:9846487
Biological Process	GO:1900477	negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter	Slfn1	IDA		Mouse	PMID:15946944
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Slfn1	IDA		Mouse	PMID:15946944
Biological Process	GO:0042130	negative regulation of T cell proliferation	Slfn1	IDA		Mouse	PMID:18373498
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Slfn1	IDA		Mouse	PMID:18373498
Biological Process	GO:0051726	regulation of cell cycle	Slfn1	IDA		Mouse	PMID:9846487
Biological Process	GO:0016075	rRNA catabolic process	SLFN12	IDA		Human	PMID:34272366
Biological Process	GO:0016075	rRNA catabolic process	SLFN12	IMP		Human	PMID:35104454
Biological Process	GO:0042098	T cell proliferation	Slfn1	IDA		Mouse	PMID:18373498

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern