Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC48A1
  • Mouse genes Slc48a1
  • Rat genes Slc48a1
  • Zfish genes slc48a1a,slc48a1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc48a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0020037	heme binding	SLC48A1	IDA		Human	PMID:18418376
Molecular Function	GO:0015232	heme transmembrane transporter activity	SLC48A1	IDA		Human	PMID:18418376
Molecular Function	GO:0015232	heme transmembrane transporter activity	slc48a1b	IDA		Zfish	PMID:30248094
Molecular Function	GO:0015232	heme transmembrane transporter activity	slc48a1a	IDA		Zfish	PMID:30248094
Molecular Function	GO:0005515	protein binding	SLC48A1	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SLC48A1	IPI	UniProtKB:P11279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC48A1	IPI	UniProtKB:P21964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC48A1	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC48A1	IPI	UniProtKB:Q86WB7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC48A1	IPI	UniProtKB:Q96B96	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC48A1	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Cellular Component	GO:0010008	endosome membrane	SLC48A1	IDA		Human	PMID:18418376
Cellular Component	GO:0005765	lysosomal membrane	SLC48A1	IDA		Human	PMID:18418376
Cellular Component	GO:0005764	lysosome	slc48a1b	IDA		Zfish	PMID:30248094
Cellular Component	GO:0005764	lysosome	slc48a1a	IDA		Zfish	PMID:30248094
Cellular Component	GO:0005886	plasma membrane	SLC48A1	IDA		Human	PMID:18418376
Biological Process	GO:0048821	erythrocyte development	slc48a1b	IMP	ZFIN:ZDB-MRPHLNO-081009-4	Zfish	PMID:18418376
Biological Process	GO:0015886	heme transport	SLC48A1	IMP		Human	PMID:23395172
Biological Process	GO:0015886	heme transport	SLC48A1	IDA		Human	PMID:18418376
Biological Process	GO:0015886	heme transport	slc48a1a	IDA		Zfish	PMID:30248094|ZFIN:ZDB-PUB-180925-9
Biological Process	GO:0055085	transmembrane transport	slc48a1a	IDA		Zfish	PMID:30248094|ZFIN:ZDB-PUB-180925-9

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern