Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC26A3
  • Mouse genes Slc26a3
  • Rat genes Slc26a3
  • Zfish genes slc26a3.1,slc26a3.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc26a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015106	bicarbonate transmembrane transporter activity	Slc26a3	IMP		Mouse	MGI:MGI:5429843|PMID:21976599
Molecular Function	GO:0015108	chloride transmembrane transporter activity	Slc26a3	IMP		Mouse	MGI:MGI:5429843|PMID:21976599
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	SLC26A3	IDA		Human	PMID:16606687
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	SLC26A3	IDA		Human	PMID:19321737
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	SLC26A3	IDA		Human	PMID:22159084
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	SLC26A3	IDA		Human	PMID:22627094
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	Slc26a3	IDA		Mouse	MGI:MGI:1342137|PMID:10428871
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	Slc26a3	IDA		Mouse	MGI:MGI:5429843|PMID:21976599
Molecular Function	GO:0005515	protein binding	SLC26A3	IPI	UniProtKB:Q15599	Human	PMID:12369822
Molecular Function	GO:0005515	protein binding	SLC26A3	IPI	UniProtKB:Q86UT5	Human	PMID:22627094
Molecular Function	GO:0005515	protein binding	Slc26a3	IPI	UniProtKB:Q8CIW6	Mouse	MGI:MGI:5429843|PMID:21976599
Molecular Function	GO:0005515	protein binding	Slc26a3	IPI	UniProtKB:Q99MJ6	Mouse	MGI:MGI:7434538|PMID:22627094
Molecular Function	GO:0005515	protein binding	Slc26a3	IPI	UniProtKB:P26361|UniProtKB:P70441|UniProtKB:Q8CIW6	Mouse	MGI:MGI:5429843|PMID:21976599
Molecular Function	GO:0005515	protein binding	Slc26a3	IPI	UniProtKB:P26361|UniProtKB:P70441	Mouse	MGI:MGI:5429843|PMID:21976599
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	slc26a3.1	IMP	ZFIN:ZDB-MRPHLNO-091216-1	Zfish	PMID:19801433
Cellular Component	GO:0016324	apical plasma membrane	Slc26a3	IDA		Rat	PMID:11052990|RGD:1600012
Cellular Component	GO:0031526	brush border membrane	Slc26a3	IDA		Rat	PMID:11875004|RGD:727349
Cellular Component	GO:0016020	membrane	Slc26a3	IDA		Mouse	MGI:MGI:5429843|PMID:21976599
Cellular Component	GO:0005886	plasma membrane	SLC26A3	IDA		Human	PMID:19321737
Cellular Component	GO:0005886	plasma membrane	SLC26A3	IDA		Human	PMID:22159084
Cellular Component	GO:0005886	plasma membrane	SLC26A3	IDA		Human	PMID:22627094
Cellular Component	GO:0097225	sperm midpiece	Slc26a3	IDA		Mouse	MGI:MGI:5429843|PMID:21976599
Biological Process	GO:0071320	cellular response to cAMP	Slc26a3	IDA		Mouse	MGI:MGI:5429843|PMID:21976599
Biological Process	GO:0006821	chloride transport	slc26a3.1	IMP	ZFIN:ZDB-MRPHLNO-091216-1	Zfish	PMID:19801433
Biological Process	GO:0051454	intracellular pH elevation	Slc26a3	IMP		Mouse	MGI:MGI:5429843|PMID:21976599
Biological Process	GO:0060081	membrane hyperpolarization	Slc26a3	IMP		Mouse	MGI:MGI:5429843|PMID:21976599
Biological Process	GO:0055081	monoatomic anion homeostasis	slc26a3.1	IDA		Zfish	PMID:19641131
Biological Process	GO:0009651	response to salt stress	slc26a3.1	IDA		Zfish	PMID:19641131
Biological Process	GO:0048240	sperm capacitation	Slc26a3	IMP		Mouse	MGI:MGI:5429843|PMID:21976599

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern