Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC15A4
  • Mouse genes Slc15a4
  • Rat genes Slc15a4
  • Zfish genes slc15a4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc15a4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071916	dipeptide transmembrane transporter activity	SLC15A4	IDA		Human	PMID:29224352
Molecular Function	GO:0071916	dipeptide transmembrane transporter activity	SLC15A4	IDA		Human	PMID:31073693
Molecular Function	GO:0005290	L-histidine transmembrane transporter activity	SLC15A4	IDA		Human	PMID:25238095
Molecular Function	GO:0005290	L-histidine transmembrane transporter activity	SLC15A4	IDA		Human	PMID:29224352
Molecular Function	GO:0005290	L-histidine transmembrane transporter activity	Slc15a4	IMP		Mouse	MGI:MGI:6192142|PMID:29784761
Molecular Function	GO:0005290	L-histidine transmembrane transporter activity	Slc15a4	IDA		Mouse	MGI:MGI:6278628|PMID:21277849
Molecular Function	GO:0005290	L-histidine transmembrane transporter activity	Slc15a4	IMP		Rat	PMID:9092568|RGD:1299463
Molecular Function	GO:0015333	peptide:proton symporter activity	SLC15A4	IDA		Human	PMID:25238095
Molecular Function	GO:0015333	peptide:proton symporter activity	SLC15A4	IDA		Human	PMID:29224352
Molecular Function	GO:0015333	peptide:proton symporter activity	Slc15a4	IMP		Mouse	MGI:MGI:6192142|PMID:29784761
Molecular Function	GO:0015647	peptidoglycan transmembrane transporter activity	SLC15A4	IDA		Human	PMID:25238095
Molecular Function	GO:0015647	peptidoglycan transmembrane transporter activity	SLC15A4	IDA		Human	PMID:29224352
Molecular Function	GO:0005515	protein binding	SLC15A4	IPI	UniProtKB:Q8IY34	Human	PMID:24695226
Molecular Function	GO:0005515	protein binding	SLC15A4	IPI	UniProtKB:Q9HC29	Human	PMID:24695226
Molecular Function	GO:0005515	protein binding	SLC15A4	IPI	UniProtKB:Q9HAI6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SLC15A4	IPI	UniProtKB:Q9HAI6	Human	PMID:32433612
Cellular Component	GO:0031901	early endosome membrane	Slc15a4	IDA		Mouse	MGI:MGI:6450424|PMID:19570976
Cellular Component	GO:0036020	endolysosome membrane	SLC15A4	IDA		Human	PMID:32433612
Cellular Component	GO:0010008	endosome membrane	Slc15a4	IDA		Mouse	MGI:MGI:5571205|PMID:24695226
Cellular Component	GO:0010008	endosome membrane	Slc15a4	IDA		Mouse	MGI:MGI:6192142|PMID:29784761
Cellular Component	GO:0005765	lysosomal membrane	SLC15A4	IDA		Human	PMID:25238095
Cellular Component	GO:0005765	lysosomal membrane	SLC15A4	IDA		Human	PMID:29224352
Cellular Component	GO:0005765	lysosomal membrane	Slc15a4	IDA		Mouse	MGI:MGI:5571205|PMID:24695226
Cellular Component	GO:0005765	lysosomal membrane	Slc15a4	IDA		Mouse	MGI:MGI:6278628|PMID:21277849
Cellular Component	GO:0005765	lysosomal membrane	Slc15a4	IDA		Mouse	MGI:MGI:6112943|PMID:29155995
Biological Process	GO:0140206	dipeptide import across plasma membrane	SLC15A4	IDA		Human	PMID:29224352
Biological Process	GO:0140206	dipeptide import across plasma membrane	SLC15A4	IDA		Human	PMID:31073693
Biological Process	GO:0015817	histidine transport	Slc15a4	IMP		Rat	PMID:9092568|RGD:1299463
Biological Process	GO:0089708	L-histidine transmembrane export from vacuole	Slc15a4	IMP		Mouse	MGI:MGI:5897714|PMID:27845049
Biological Process	GO:0033023	mast cell homeostasis	Slc15a4	IMP		Mouse	MGI:MGI:6112943|PMID:29155995
Biological Process	GO:0015835	peptidoglycan transport	SLC15A4	IDA		Human	PMID:25238095
Biological Process	GO:0015835	peptidoglycan transport	SLC15A4	IDA		Human	PMID:29224352
Biological Process	GO:0015835	peptidoglycan transport	Slc15a4	IMP		Mouse	MGI:MGI:6192142|PMID:29784761
Biological Process	GO:0015835	peptidoglycan transport	Slc15a4	IDA		Mouse	MGI:MGI:5571205|PMID:24695226
Biological Process	GO:0045089	positive regulation of innate immune response	SLC15A4	IDA		Human	PMID:32433612
Biological Process	GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:6278628|PMID:21277849
Biological Process	GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:6450424|PMID:19570976
Biological Process	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	Slc15a4	IDA		Mouse	MGI:MGI:5571205|PMID:24695226
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	SLC15A4	IMP		Human	PMID:25238095
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	SLC15A4	IMP		Human	PMID:32433612
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:6357091|PMID:25238095
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:4848237|PMID:21045126
Biological Process	GO:0034161	positive regulation of toll-like receptor 8 signaling pathway	SLC15A4	IMP		Human	PMID:32433612
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	SLC15A4	IMP		Human	PMID:25238095
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:6357091|PMID:25238095
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:4848237|PMID:21045126
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:6278628|PMID:21277849
Biological Process	GO:0048302	regulation of isotype switching to IgG isotypes	Slc15a4	IMP		Mouse	MGI:MGI:5649169|PMID:25310967
Biological Process	GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway	Slc15a4	IMP		Mouse	MGI:MGI:6192142|PMID:29784761

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern