Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC12A6
  • Mouse genes Slc12a6
  • Rat genes Slc12a6
  • Zfish genes slc12a6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc12a6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	SLC12A6	IDA		Human	PMID:12657561
Molecular Function	GO:0015379	potassium:chloride symporter activity	SLC12A6	IDA		Human	PMID:10187864
Molecular Function	GO:0015379	potassium:chloride symporter activity	SLC12A6	IDA		Human	PMID:10600773
Molecular Function	GO:0015379	potassium:chloride symporter activity	SLC12A6	IDA		Human	PMID:11551954
Molecular Function	GO:0015379	potassium:chloride symporter activity	SLC12A6	IDA		Human	PMID:16048901
Molecular Function	GO:0015379	potassium:chloride symporter activity	SLC12A6	IDA		Human	PMID:34031912
Molecular Function	GO:0015379	potassium:chloride symporter activity	Slc12a6	IDA		Mouse	MGI:MGI:1337957|PMID:10347194
Molecular Function	GO:0005515	protein binding	Slc12a6	IPI	PR:Q9Z1W9	Mouse	PMID:12386165
Molecular Function	GO:0005515	protein binding	Slc12a6	IPI	PR:Q6P9R2	Mouse	PMID:12386165
Molecular Function	GO:0019901	protein kinase binding	Slc12a6	IPI	UniProtKB:O55047|UniProtKB:P09411|UniProtKB:Q6P9R2|UniProtKB:Q8C0P0|UniProtKB:Q9JLN9|UniProtKB:Q9Z1W9	Mouse	MGI:MGI:6221361|PMID:27782176
Cellular Component	GO:0030424	axon	Slc12a6	IDA		Mouse	PMID:11246162
Cellular Component	GO:0016323	basolateral plasma membrane	Slc12a6	IDA		Mouse	MGI:MGI:5284789|PMID:16048901
Cellular Component	GO:0016323	basolateral plasma membrane	Slc12a6	IDA		Mouse	PMID:11246162
Cellular Component	GO:0005886	plasma membrane	Slc12a6	IDA		Mouse	MGI:MGI:1337957|PMID:10347194
Biological Process	GO:0140157	ammonium import across plasma membrane	SLC12A6	IDA		Human	PMID:12657561
Biological Process	GO:0071477	cellular hypotonic salinity response	SLC12A6	IDA		Human	PMID:16048901
Biological Process	GO:0071333	cellular response to glucose stimulus	Slc12a6	IDA		Mouse	PMID:24089410
Biological Process	GO:0055064	chloride ion homeostasis	Slc12a6	IDA		Mouse	MGI:MGI:1337957|PMID:10347194
Biological Process	GO:0006811	monoatomic ion transport	SLC12A6	IDA		Human	PMID:10187864
Biological Process	GO:0055075	potassium ion homeostasis	Slc12a6	IDA		Mouse	MGI:MGI:1337957|PMID:10347194
Biological Process	GO:0071805	potassium ion transmembrane transport	SLC12A6	IDA		Human	PMID:11551954

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern