Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIK3
  • Mouse genes Sik3
  • Rat genes Sik3
  • Zfish genes sik3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sik3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	SIK3	IDA		Human	PMID:14976552
Molecular Function	GO:0000287	magnesium ion binding	SIK3	IDA		Human	PMID:14976552
Molecular Function	GO:0005515	protein binding	SIK3	IPI	UniProtKB:P63104	Human	PMID:16306228
Molecular Function	GO:0005515	protein binding	SIK3	IPI	UniProtKB:Q6R327|UniProtKB:Q8N122|UniProtKB:Q8TB45|UniProtKB:Q9BVC4	Human	PMID:30232230
Molecular Function	GO:0005515	protein binding	Sik3	IPI	PR:Q6NZM9	Mouse	PMID:22318228
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SIK3	IDA		Human	PMID:14976552
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SIK3	IDA		Human	PMID:30232230
Cellular Component	GO:0005737	cytoplasm	Sik3	IDA		Mouse	PMID:22318228
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Sik3	IMP	MGI:MGI:5317918	Mouse	PMID:22318228
Biological Process	GO:0001958	endochondral ossification	Sik3	IMP	MGI:MGI:5317918	Mouse	PMID:22318228
Biological Process	GO:0035108	limb morphogenesis	Sik3	IMP	MGI:MGI:5317918	Mouse	PMID:22318228
Biological Process	GO:0035264	multicellular organism growth	Sik3	IMP	MGI:MGI:5317918	Mouse	PMID:22318228
Biological Process	GO:1904263	positive regulation of TORC1 signaling	SIK3	IMP		Human	PMID:30232230
Biological Process	GO:1904515	positive regulation of TORC2 signaling	SIK3	IMP		Human	PMID:30232230
Biological Process	GO:0006468	protein phosphorylation	SIK3	IDA		Human	PMID:14976552
Biological Process	GO:0032880	regulation of protein localization	Sik3	IMP	MGI:MGI:5317918	Mouse	PMID:22318228
Biological Process	GO:0048705	skeletal system morphogenesis	Sik3	IMP	MGI:MGI:5317918	Mouse	PMID:22318228

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern